Sowjanya B Lakshmi, Devi K Rudrama, Madhavi D
Department of Zoology, Osmania University, Hyderabad-500 007, India.
J Environ Biol. 2009 Sep;30(5):663-6.
Cyclophosphamide (CP) is a commonly used chemotherapeutic and immunosuppressive agent which is used in the treatment of wide range of cancers and autoimmune diseases. Besides that it is a well known carcinogen. In this study by using chromosomal aberrations (CA) and sister chromatid exchanges (SCE) assays method, the modulatory effects exerted by the extract of garlic against the CP induced genotoxicity in the human lymphocyte cultures in vitro were tested. Three different doses of garlic extract were tested for their modulatory capacity on the mutagenecity exerted by 100 microg ml(-1) of CR The results indicate a significant decrease in the frequency of CA and SCE suggesting that the garlic extract modulates the CP induced genotoxicity in a dose dependent manner. These findings provide the future directions for the research on design and development of possible modulatory drugs containing garlic extract.
环磷酰胺（CP）是一种常用的化疗和免疫抑制剂，用于治疗多种癌症和自身免疫性疾病。除此之外，它还是一种众所周知的致癌物。在本研究中，采用染色体畸变（CA）和姐妹染色单体交换（SCE）检测方法，测试了大蒜提取物对体外人淋巴细胞培养物中CP诱导的遗传毒性的调节作用。测试了三种不同剂量的大蒜提取物对100微克/毫升CP所致致突变性的调节能力。结果表明，CA和SCE的频率显著降低，这表明大蒜提取物以剂量依赖的方式调节CP诱导的遗传毒性。这些发现为含有大蒜提取物的可能调节药物的设计和开发研究提供了未来方向。
