Department of Radiation Medicine, Chan Shun Pavilion, 11175 Campus Street, Loma Linda University, Loma Linda, CA 92354, USA.
Expert Rev Neurother. 2010 Feb;10(2):319-30. doi: 10.1586/ern.09.150.
The focus of this review is proton radiotherapy for primary neoplasms of the brain. Although glial cells are among the most radioresistant in the body, the presence of sensitive critical structures and the high doses needed to control CNS tumors present a formidable challenge to the treating radiation oncologist. Treatment with conventional photon radiation at doses required to control disease progression all too often results in unacceptable toxicity. Protons have intrinsic properties that often allow radiation oncologists to deliver a higher dose to the tumor compared with photons, while at the same time offering better sparing of normal tissues. Recognition of these advantages has resulted in development of many new proton treatment facilities worldwide.
本次综述的重点是质子放射疗法治疗原发性脑肿瘤。尽管神经胶质细胞是人体中对放射线抗性最强的细胞之一，但由于存在敏感的关键结构和控制中枢神经系统肿瘤所需的高剂量，这给治疗放射肿瘤学家带来了巨大的挑战。用常规光子放疗，剂量达到控制疾病进展的要求，往往会导致无法接受的毒性。质子具有内在特性，这通常使放射肿瘤学家能够与光子相比为肿瘤提供更高的剂量，同时更好地保护正常组织。认识到这些优势，已经导致全球许多新的质子治疗设施的发展。
