Levin W P, Kooy H, Loeffler J S, DeLaney T F
Massachusetts General Hospital Northeast Proton Therapy Center, Boston, MA 02114, USA.
Br J Cancer. 2005 Oct 17;93(8):849-54. doi: 10.1038/sj.bjc.6602754.
Conventional radiation therapy directs photons (X-rays) and electrons at tumours with the intent of eradicating the neoplastic tissue while preserving adjacent normal tissue. Radiation-induced damage to healthy tissue and second malignancies are always a concern, however, when administering radiation. Proton beam radiotherapy, one form of charged particle therapy, allows for excellent dose distributions, with the added benefit of no exit dose. These characteristics make this form of radiotherapy an excellent choice for the treatment of tumours located next to critical structures such as the spinal cord, eyes, and brain, as well as for paediatric malignancies.
传统放射治疗通过向肿瘤发射光子（X射线）和电子，旨在根除肿瘤组织，同时保护相邻的正常组织。然而，在进行放射治疗时，辐射对健康组织造成的损伤和继发性恶性肿瘤始终是令人担忧的问题。质子束放射治疗作为带电粒子治疗的一种形式，能够实现出色的剂量分布，并且没有出射剂量这一额外优势。这些特性使这种放射治疗形式成为治疗位于脊髓、眼睛和大脑等关键结构附近的肿瘤以及儿童恶性肿瘤的理想选择。
