Department of Physiology, Meram Faculty of Medicine, Selçuk University, Konya, Turkey.
J Med Food. 2010 Feb;13(1):216-8. doi: 10.1089/jmf.2008.0310.
The aim of the study was to determine the effects of coenzyme Q10 supplementation on plasma adiponectin, interleukin (IL)-6, and tumor necrosis factor (TNF )-alpha levels in sedentary men. Fourteen healthy, nonsmoking, sedentary men participated in the study. The protocol was approved by the Ethical Committee of our institution. This study was a randomized, double-blind, crossover trial. Blood samples were collected from all participants before coenzyme Q10 or placebo supplementation. The participants were randomly allocated to two groups. Seven participants received oral coenzyme Q10 (100 mg/day) supplementation, and seven participants received placebo (glucose) for 8 weeks. At the end of the 8 weeks, a second blood sampling was performed. After a 4-week washout period, placebo was given to the participants who used coenzyme Q10 the first time, and vice versa, and blood sampling was repeated. Plasma was stored at -80 degrees C until the time of analysis for adiponectin, IL-6, and TNF-alpha. Both CoQ10 and placebo supplementation did not affect plasma adiponectin and TNF-alpha levels. IL-6 level increased with coenzyme Q10 supplementation, but this increase did not differ from that seen with placebo supplementation. Coenzyme Q10 supplementation did not affect plasma adiponectin, IL-6, and TNF-alpha levels in sedentary men.
本研究旨在确定辅酶 Q10 补充对久坐男性血浆脂联素、白细胞介素 (IL)-6 和肿瘤坏死因子 (TNF)-α水平的影响。14 名健康、不吸烟、久坐的男性参与了这项研究。该方案已获得我们机构伦理委员会的批准。这是一项随机、双盲、交叉试验。所有参与者在辅酶 Q10 或安慰剂补充前采集血样。参与者被随机分配到两组。7 名参与者接受口服辅酶 Q10（100mg/天）补充，7 名参与者接受安慰剂（葡萄糖）补充 8 周。8 周结束时进行第二次采血。经过 4 周的洗脱期后，第一次使用辅酶 Q10 的参与者给予安慰剂，反之亦然，并重复采血。血浆在-80°C 下储存，直到分析脂联素、IL-6 和 TNF-α。辅酶 Q10 和安慰剂补充均未影响血浆脂联素和 TNF-α水平。IL-6 水平随辅酶 Q10 补充而升高，但与安慰剂补充相比无差异。辅酶 Q10 补充并未影响久坐男性的血浆脂联素、IL-6 和 TNF-α水平。
