补充辅酶Q10对男性跑步者运动诱导的炎症指标和血乳酸反应的影响。
Effect of coenzyme Q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners.
作者信息
Armanfar Mostafa, Jafari Afshar, Dehghan Gholam Reza, Abdizadeh Leila
机构信息
PhD Student of Exercise Physiology, Exercise Physiology Department, University of Tabriz, Tabriz, Iran.
Associate Professor of Sport Physiology, Department of Physical Education, University of Tabriz, Tabriz, Iran.
出版信息
Med J Islam Repub Iran. 2015 Apr 20;29:202. eCollection 2015.
BACKGROUND
Heavy exercise cause muscle damage associated with production of inflammatory agents. The purpose of present study was to determine the effect of acute and 14-day Coenzyme Q10 supplementation on inflammatory, blood lactate and muscle damage in male middle-distance runners.
METHODS
Eighteen male middle-distance runners in a randomized and quasi experimental study were allocated into two equal groups: supplement group (n=9, Coenzyme Q10: 5mg/kg/day) and placebo group (n= 9, Dextrose: 5mg/kg/day). After acute (1day) and 14-day supplementation, all subjects were participated in a training like running (competitive 3000 meters). Blood samples were obtained in the four phases: one hour before and 18-24 hours after two running protocols. Lactate, serum interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP) and creatine kinase (CK) were analyzed. Repeated ANOVA and Bonferuni as a post hoc tests were used to determine the changes in four stages. Differences between groups were determined by t-test.
RESULTS
The results showed that acute and short-term Coenzyme Q10 supplementation had not significant effect on basal parameters. The acute coenzyme Q10 supplementation attenuated only the exercise-induced increase in response of the plasma CRP. The short-term (14-day) coenzyme Q10 supplementation attenuated the exercise-induced increase in response of the lactate, serum interleukin- 6, tumor necrosis factor-alpha, and CRP in male middle-distance runners. However, the acute and short-term coenzyme Q10 supplementation had not any significant effect on the exerciseinduced increase response of total serum creatine kinase.
CONCLUSION
Based on the present results, it can be concluded that the 14-day coenzyme Q10 supplementation (5mg.kg-1.day-1) is more effective than the acute supplementation to overcome the exercise-induced adverse responses in some oxidative, inflammatory and biochemical parameters. Therefore, short-term coenzyme Q10 supplementation is recommended to reduce exercise-induced adverse consequences.
背景
高强度运动可导致与炎症介质产生相关的肌肉损伤。本研究的目的是确定急性和14天补充辅酶Q10对男性中长跑运动员炎症、血乳酸和肌肉损伤的影响。
方法
在一项随机半实验研究中，18名男性中长跑运动员被分为两组，每组人数相等：补充组（n = 9，辅酶Q10：5mg/kg/天）和安慰剂组（n = 9，葡萄糖：5mg/kg/天）。在急性（1天）和14天补充后，所有受试者都参加了一次类似跑步的训练（3000米竞争性跑步）。在四个阶段采集血样：两次跑步方案前1小时和后18 - 24小时。分析乳酸、血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）和肌酸激酶（CK）。采用重复方差分析和Bonferuni事后检验来确定四个阶段的变化。通过t检验确定组间差异。
结果
结果表明，急性和短期补充辅酶Q10对基础参数没有显著影响。急性补充辅酶Q10仅减弱了运动诱导的血浆CRP反应增加。短期（14天）补充辅酶Q10减弱了运动诱导的男性中长跑运动员乳酸、血清白细胞介素-6、肿瘤坏死因子-α和CRP反应增加。然而，急性和短期补充辅酶Q10对运动诱导的总血清肌酸激酶反应增加没有任何显著影响。
结论
基于目前的结果，可以得出结论，14天补充辅酶Q10（5mg·kg-1·day-1）在克服运动诱导的某些氧化、炎症和生化参数的不良反应方面比急性补充更有效。因此，建议短期补充辅酶Q10以减少运动诱导的不良后果。
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