Department of Experimental Therapeutics, Kyungpook National University, Taegu, Republic of Korea.
Endocr Res. 2010 Jan;35(1):1-16. doi: 10.3109/07435800903524161.
Pomegranate (Punica granatum) seed linolenic acid isomers were evaluated as selective estrogen receptor modulators (SERMs) in vitro. Punicic acid (PA) inhibited (IC(50)) estrogen receptor (ER) alpha at 7.2 microM, ERbeta at 8.8 microM; alpha-eleostearic acid (AEA) inhibited ERalpha/ERbeta at 6.5/7.8 microM. PA (not AEA) agonized ERalpha/ERbeta (EC(50)) at 1.8/2 microM, antagonizing at 101/80 microM. AEA antagonized ERalpha/ERbeta at 150/140 microM. PA and AEA induced ERalpha and ERbeta mRNA expression in MCF-7, but not in MDA-MB-231. Overall, the results show PA and AEA are SERMs.
石榴（Punica granatum）籽油中亚麻酸异构体被评估为体外选择性雌激素受体调节剂（SERMs）。 pununic 酸（PA）抑制雌激素受体（ER）alpha 的 IC50 为 7.2μM，抑制 ERbeta 的 IC50 为 8.8μM；α-桐酸（AEA）抑制 ERalpha/ERbeta 的 IC50 为 6.5/7.8μM。PA（而非 AEA）激动 ERalpha/ERbeta 的 EC50 为 1.8/2μM，拮抗作用的 EC50 为 101/80μM。AEA 拮抗 ERalpha/ERbeta 的 EC50 为 150/140μM。PA 和 AEA 诱导 MCF-7 中 ERalpha 和 ERbeta mRNA 的表达，但在 MDA-MB-231 中没有诱导。总的来说，这些结果表明 PA 和 AEA 是 SERMs。
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