细胞外钙敏感受体的多模态传感机制：基于结构域的结合和信号转导要求调查。
Mechanisms of multimodal sensing by extracellular Ca(2+)-sensing receptors: a domain-based survey of requirements for binding and signalling.
机构信息
University of Sydney, NSW, Australia.
出版信息
Br J Pharmacol. 2010 Mar;159(5):1039-50. doi: 10.1111/j.1476-5381.2009.00603.x. Epub 2010 Feb 5.
Abstract
In this article we consider the molecular basis of sensing and signalling by the extracellular calcium-sensing receptor. We consider the nature of its ligands and sensing modalities, the identities of its major protein domains and their roles in sensing, signalling and trafficking as well as the significance of receptor homo- and hetero-dimerization. Finally, we consider the current, incomplete, state of knowledge regarding the requirements for ligand-specific signalling.
摘要
在本文中，我们探讨了细胞外钙敏感受体的感应和信号转导的分子基础。我们探讨了其配体的性质和感应方式、主要蛋白结构域的身份及其在感应、信号转导和运输中的作用，以及受体同型和异型二聚化的意义。最后，我们还探讨了目前关于配体特异性信号转导要求的不完全知识状态。
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