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益生菌干预对急性犬肠胃炎的影响——一项对照临床试验

Effects of a probiotic intervention in acute canine gastroenteritis--a controlled clinical trial.

作者信息

Herstad H K, Nesheim B B, L'Abée-Lund T, Larsen S, Skancke E

机构信息

Petvett Ekeberg Small Animal Clinic, Ekebergveien 177, 1177 Oslo, Norway.

出版信息

J Small Anim Pract. 2010 Jan;51(1):34-8. doi: 10.1111/j.1748-5827.2009.00853.x.

Abstract

OBJECTIVES

To evaluate the effect of a probiotic product in acute self-limiting gastroenteritis in dogs.

METHODS

Thirty-six dogs suffering from acute diarrhoea or acute diarrhoea and vomiting were included in the study. The trial was performed as a randomised, double blind and single centre study with stratified parallel group design. The animals were allocated to equal looking probiotic or placebo treatment by block randomisation with a fixed block size of six. The probiotic cocktail consisted of thermo-stabilised Lactobacillus acidophilus and live strains of Pediococcus acidilactici, Bacillus subtilis, Bacillus licheniformis and Lactobacillus farciminis.

RESULTS

The time from initiation of treatment to the last abnormal stools was found to be significantly shorter (P = 0.04) in the probiotic group compared to placebo group, the mean time was 1.3 days and 2.2 days, respectively. The two groups were found nearly equal with regard to time from start of treatment to the last vomiting episode.

CLINICAL SIGNIFICANCE

The probiotic tested may reduce the convalescence time in acute self-limiting diarrhoea in dogs.

摘要

目的

评估一种益生菌产品对犬急性自限性胃肠炎的疗效。

方法

36只患有急性腹泻或急性腹泻伴呕吐的犬被纳入该研究。试验采用随机、双盲、单中心研究,分层平行组设计。通过固定区组大小为6的区组随机化,将动物分配到外观相同的益生菌或安慰剂治疗组。益生菌混合物由热稳定嗜酸乳杆菌以及嗜酸片球菌、枯草芽孢杆菌、地衣芽孢杆菌和豕链球菌的活菌株组成。

结果

发现益生菌组从开始治疗到最后一次异常粪便的时间明显短于安慰剂组(P = 0.04),平均时间分别为1.3天和2.2天。两组从开始治疗到最后一次呕吐发作的时间几乎相等。

临床意义

所测试的益生菌可能会缩短犬急性自限性腹泻的恢复期。

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