肿瘤诱导耐受中的吲哚胺 2,3-双加氧酶。
Indoleamine 2,3-dioxygenase in tumor induced tolerance.
机构信息
Department of Hematology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.
出版信息
Chin Med J (Engl). 2009 Dec 20;122(24):3072-7.
OBJECTIVE
To review the recent studies about the role of indoleamine 2,3-dioxygenase (IDO) in tumor induced tolerance.
DATA SOURCES
Published articles (1978 - 2009) on IDO and tumor induced tolerance were selected from Medline.
STUDY SELECTION
Articles selected were relevant to development of IDO in tumor induced tolerance. Of all originally identified articles, 50 specially addressed the stated purpose.
RESULTS
Recent work has revealed IDO at high levels in tumors and in tumor-draining lymph nodes and a close relationship between IDO activity and the regulatory T cells.
CONCLUSION
Up-regulation of IDO is proven to be a mechanism of acquired tolerance in tumors, in which the closely coupled positive feedback system between IDO and regulatory T cells may be considered to play an important role.
目的
综述吲哚胺 2,3-双加氧酶（IDO）在肿瘤诱导免疫耐受中的作用的最新研究进展。
资料来源
检索 Medline 数据库中 1978 年至 2009 年发表的有关 IDO 与肿瘤诱导免疫耐受的文献。
研究选择
选择与肿瘤诱导免疫耐受中 IDO 表达相关的文章。最初确定的所有文章中，有 50 篇专门针对上述目的。
结果
最近的研究表明 IDO 在肿瘤组织和引流淋巴结中高表达，IDO 活性与调节性 T 细胞之间存在密切关系。
结论
IDO 的上调被证实是肿瘤获得性耐受的一种机制，其中 IDO 和调节性 T 细胞之间的紧密偶联正反馈系统可能发挥重要作用。
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