Huang Xian-sheng, Zhao Shui-ping, Zhang Qian, Bai Lin, Hu Min, Zhao Wang
Department of Cardiology, Second Xiang Ya Hospital, Central South University, Changsha 410011, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Oct;37(10):896-9.
To explore the relationship between serum apolipoprotein A5 (ApoA5) and lipid profile or high sensitive C-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS).
Serum apoA5 and hs-CRP levels were measured by ELISA and immunoturbidimetry in control subjects (n = 232), patients with stable angina (SA, n = 127), unstable angina (UA, n = 116) and acute myocardial infarction (AMI, n = 112). Triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were also measured.
Compared with controls [(108.7 +/- 23.2) microg/L] and SA patients [(78.3 +/- 20.2) microg/L], serum ApoA5 level was significantly increased in UA [(340.6 +/- 63.5) microg/L] and AMI patients [(373.2 +/- 73.8) microg/L] (all P < 0.05). ApoA5 was positively correlated with TG (r = 0.63 and 0.67, respectively, all P < 0.05) and hs-CRP (r = 0.57 and 0.55, respectively, all P < 0.05) in UA and AMI patients but there were no significant correlations between ApoA5 and TC, HDL-C and LDL-C in ACS patients (all P > 0.05).
Increased serum apoA5 level and the positive correlation between ApoA5 and serum TG and hs-CRP in ACS patients might reflect increased inflammation responses in ACS patients.
探讨急性冠脉综合征（ACS）患者血清载脂蛋白A5（ApoA5）与血脂谱或高敏C反应蛋白（hs-CRP）之间的关系。
采用酶联免疫吸附测定法（ELISA）和免疫比浊法分别检测232例对照者、127例稳定型心绞痛（SA）患者、116例不稳定型心绞痛（UA）患者和112例急性心肌梗死（AMI）患者的血清ApoA5和hs-CRP水平。同时检测甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平。
与对照组[（108.7±23.2）μg/L]和SA患者[（78.3±20.2）μg/L]相比，UA患者[（340.6±63.5）μg/L]和AMI患者[（373.2±73.8）μg/L]的血清ApoA5水平显著升高（均P<0.05）。在UA和AMI患者中，ApoA5与TG（r分别为0.63和0.67，均P<0.05）及hs-CRP（r分别为0.57和0.55，均P<0.05）呈正相关，但在ACS患者中ApoA5与TC、HDL-C和LDL-C之间无显著相关性（均P>0.05）。
ACS患者血清ApoA5水平升高以及ApoA5与血清TG和hs-CRP之间的正相关可能反映了ACS患者炎症反应增强。
