Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Atherosclerosis. 2010 Jul;211(1):283-6. doi: 10.1016/j.atherosclerosis.2010.01.017. Epub 2010 Jan 25.
Red wine consumption may influence on vasoconstrictive peptide endothelin-1 levels, and this may be one mechanism leading to improved vasodilation after red wine consumption. Endothelin-1 levels and their association with coronary epicardial diameter and flow rate, however, have not been studied in vivo after consumption of red wine and de-alcoholized red wine. The purpose of this randomized trial was to determine the acute effects of these beverages on endothelin-1 levels and compare them to coronary artery epicardial diameter and flow rate.
Twenty-two healthy men consumed a high dose (8.1+/-0.9 dL) of alcohol-containing red wine and de-alcoholized red wine in a cross-over design at one sitting with a two-week washout period. Endothelin-1 levels were determined and coronary artery diameter and flow rate assessed using transthoracic echocardiography before and acutely after intervention.
Red wine and de-alcoholized red wine significantly decreased endothelin-1 levels (0.75+/-0.26 pg/mL to 0.61+/-0.20 pg/mL, p=0.002; 0.74+/-0.32 pg/mL to 0.63+/-0.24 pg/mL, p=0.04, respectively), but did not have a significant effect on epicardial diameter (1.1+/-0.3 mm vs. 1.1+/-0.3 mm, p=0.58; and 1.1+/-0.3 mm vs. 1.1+/-0.2 mm, p=0.10, respectively) or flow rate (7.8+/-4.0 mL/min to 6.4+/-3.6 mL/min, p=0.07; and 7.8+/-4.0 mL/min to 7.4+/-3.2 mL/min, p=0.53, respectively).
Red wine and de-alcoholized red wine decreased plasma endothelin-1 levels after acute consumption, but this change was not reflected in coronary epicardial diameters or flow rate.
红酒的摄入可能会影响血管收缩肽内皮素-1 的水平，这可能是红酒摄入后血管扩张改善的机制之一。然而，在摄入红酒和去酒精红酒后，内皮素-1 水平及其与冠状动脉心外膜直径和血流速率的关系尚未在体内进行研究。本随机试验的目的是确定这些饮料对内皮素-1 水平的急性影响，并将其与冠状动脉心外膜直径和血流速率进行比较。
22 名健康男性以交叉设计的方式一次饮用高剂量（8.1+/-0.9 dL）含酒精的红酒和去酒精红酒，间隔两周。在干预前后使用经胸超声心动图测定内皮素-1 水平，并评估冠状动脉直径和血流速率。
红酒和去酒精红酒均显著降低内皮素-1 水平（0.75+/-0.26 pg/mL 降至 0.61+/-0.20 pg/mL，p=0.002；0.74+/-0.32 pg/mL 降至 0.63+/-0.24 pg/mL，p=0.04），但对心外膜直径（1.1+/-0.3 mm 与 1.1+/-0.3 mm，p=0.58；1.1+/-0.3 mm 与 1.1+/-0.2 mm，p=0.10）或血流速率（7.8+/-4.0 mL/min 至 6.4+/-3.6 mL/min，p=0.07；7.8+/-4.0 mL/min 至 7.4+/-3.2 mL/min，p=0.53）均无显著影响。
红酒和去酒精红酒摄入后可降低血浆内皮素-1 水平，但这种变化并未反映在冠状动脉心外膜直径或血流速率上。
