Barden Anne E, Croft Kevin D, Beilin Lawrence J, Phillips Michael, Ledowski Thomas, Puddey Ian B
aUniversity of Western Australia, School of Medicine & Pharmacology, Royal Perth Hospital bWestern Australian Institute for Medical Research, University of Western Australia, Perth, Australia.
J Hypertens. 2013 Nov;31(11):2195-202; discussion 2202. doi: 10.1097/HJH.0b013e328364a27f.
The vasodilation accompanying acute alcohol ingestion is hard to reconcile with the strong evidence linking chronic alcohol consumption with hypertension. Cytochrome P450 (CYP450) eicosanoids derived from arachidonic acid include vasodilator epoxyeicosatrienoic acids (EETs) and the vasoconstrictor 20-hydroxyeicosatrienoic acid (20-HETE). This study aimed to examine the relationship between CYP450 eicosanoids and blood pressure (BP), and compared the effect of single session of drinking red wine with de-alcoholized red wine (DRW) or water over 24 h.
Twenty-five normotensive men were randomly assigned to drink either 375 ml of red wine (41 g of alcohol) or the equivalent volume of DRW or water, with a light meal on 3 separate days. Ambulatory BP and heart rate were measured over 24 h. Blood samples were obtained before and 2, 4 and 24 h after beverage consumption.
Blood pressure fell in the first 4 h after red wine consumption (P = 0.001), but was significantly higher after 20 h (P = 0.037). Plasma 20-HETE fell in the 2 h after consumption of all beverages, but over the 24-h period was relatively higher after red wine consumption (P = 0.025). The largest difference in 20-HETE was 2 h after consuming red wine and coincided with the highest blood alcohol level. There were no significant effects of red wine on plasma EETs.
Acute consumption of alcohol as red wine results in a relative increase in plasma levels of the vasoconstrictor 20-HETE over 24 h without affecting EETs, and may contribute to the BP elevation that associates with a binge drinking pattern or be a homeostatic response to the acute fall in BP induced by alcohol.
急性饮酒时伴随的血管舒张现象难以与长期饮酒与高血压之间的有力证据相协调。细胞色素P450（CYP450）衍生自花生四烯酸的类二十烷酸包括血管舒张性环氧二十碳三烯酸（EETs）和血管收缩性20-羟基二十碳三烯酸（20-HETE）。本研究旨在探讨CYP450类二十烷酸与血压（BP）之间的关系，并比较单次饮用红酒与脱醇红酒（DRW）或水24小时后的效果。
25名血压正常的男性被随机分配饮用375毫升红酒（41克酒精）或等量的DRW或水，并在3个不同的日子里搭配清淡餐食。在24小时内测量动态血压和心率。在饮用饮料前以及饮用后2、4和24小时采集血样。
饮用红酒后前4小时血压下降（P = 0.001），但20小时后显著升高（P = 0.037）。饮用所有饮料后2小时血浆20-HETE下降，但在24小时期间，饮用红酒后相对较高（P = 0.025）。饮用红酒后2小时20-HETE的差异最大，且与最高血酒精水平一致。红酒对血浆EETs无显著影响。
急性饮用红酒形式的酒精会导致血管收缩剂20-HETE的血浆水平在24小时内相对升高，而不影响EETs，这可能导致与暴饮模式相关的血压升高，或者是对酒精引起的急性血压下降的一种稳态反应。
