组蛋白修饰酶在介导神经细胞类型特化中的关键作用。
Crucial roles of histone-modifying enzymes in mediating neural cell-type specification.
机构信息
Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Curr Opin Neurobiol. 2010 Feb;20(1):29-36. doi: 10.1016/j.conb.2010.01.003.
Abstract
The development of the central nervous system (CNS) is governed by networks of extrinsic and intrinsic molecular programs that together orchestrate precise gene regulation. For the past few years, significant progress has been made in the characterization of histone-modifying enzymes and the roles they play in transcriptional control by affecting chromatin structure. Importantly, recent studies have revealed dynamic changes in histone modifications over the course of neural cell-fate specification. Further understanding of physiological functions of histone-modifying enzymes and their molecular mechanisms of action in CNS development will provide crucial insights into the process of generating neural cell types with tremendous diversity. Here we discuss the recent advancement in understanding the roles of enzymes involved in histone acetylation and methylation during neural cell-type specification.
摘要
中枢神经系统（CNS）的发育受外在和内在分子程序网络的调控，这些网络共同协调精确的基因调控。在过去的几年中，在鉴定组蛋白修饰酶及其通过影响染色质结构在转录控制中所起的作用方面取得了重大进展。重要的是，最近的研究揭示了神经细胞命运特化过程中组蛋白修饰的动态变化。进一步了解组蛋白修饰酶的生理功能及其在 CNS 发育中的作用机制，将为产生具有巨大多样性的神经细胞类型的过程提供重要的见解。在这里，我们讨论了在理解参与神经细胞类型特化的组蛋白乙酰化和甲基化的酶的作用方面的最新进展。
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