孕期缺氧与脑发育障碍的表观遗传编程
Gestational hypoxia and epigenetic programming of brain development disorders.
作者信息
Ma Qingyi, Xiong Fuxia, Zhang Lubo
机构信息
Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.
出版信息
Drug Discov Today. 2014 Dec;19(12):1883-96. doi: 10.1016/j.drudis.2014.09.010. Epub 2014 Sep 26.
Abstract
Adverse environmental conditions faced by an individual early during its life, such as gestational hypoxia, can have a profound influence on the risk of diseases, such as neurological disorders, in later life. Clinical and preclinical studies suggest that epigenetic programming of gene expression patterns in response to maternal stress have a crucial role in the fetal origins of neurological diseases. Herein, we summarize recent studies regarding the role of epigenetic mechanisms in the developmental programming of neurological diseases in offspring, primarily focusing on DNA methylation/demethylation and miRNAs. Such information could increase our understanding of the fetal origins of adult diseases and help develop effective prevention and intervention against neurological diseases.
摘要
个体在生命早期面临的不利环境条件，如孕期缺氧，会对其晚年患神经系统疾病等疾病的风险产生深远影响。临床和临床前研究表明，响应母体应激的基因表达模式的表观遗传编程在神经系统疾病的胎儿起源中起着关键作用。在此，我们总结了关于表观遗传机制在后代神经系统疾病发育编程中的作用的最新研究，主要聚焦于DNA甲基化/去甲基化和微小RNA。这些信息可以增进我们对成人疾病胎儿起源的理解，并有助于开发针对神经系统疾病的有效预防和干预措施。
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