Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET), Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, S2002LRK Rosario, Argentina.
Curr Opin Microbiol. 2010 Apr;13(2):210-8. doi: 10.1016/j.mib.2009.12.012. Epub 2010 Feb 4.
Despite being considered a relatively simple form of life, bacteria have revealed a high degree of structural organization, with the spatial destination of their components precisely regulated within the cell. Nevertheless, the primary signals that dictate differential distribution of cellular building blocks and physiological processes remain in most cases largely undisclosed. Signal transduction systems are no exception within this three-dimensional organization and two-component systems (TCS) involved in controlling cell division, differentiation, chemotaxis and virulence show specific and/or dynamic localization, engaging in the spatial program of the bacterial cell.
尽管被认为是一种相对简单的生命形式，但细菌已经显示出高度的结构组织，其组成部分在细胞内的空间定位被精确调节。然而，在大多数情况下，决定细胞构建块和生理过程差异分布的主要信号仍然很大程度上未被揭示。信号转导系统在这种三维组织中也不例外，参与控制细胞分裂、分化、趋化性和毒力的双组分系统（TCS）表现出特定和/或动态的定位，参与细菌细胞的空间程序。
