Coleman R E, Hoffman J M, Hanson M W, Sostman H D, Schold S C
Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710.
J Nucl Med. 1991 Apr;32(4):616-22.
The combination of FDG and PET has demonstrated clinical utility in the evaluation of patients with brain tumors. At the time of diagnosis, FDG PET provides information concerning the degree of malignancy and patient prognosis. After therapy, FDG PET is able to assess persistence of tumor, determine degree of malignancy, monitor progression, differentiate recurrence from necrosis, and assess prognosis. Other studies using PET provide information that may be clinically useful. Determination of tumor blood flow and permeability of the blood-brain barrier may help in the selection of appropriate therapy. Amino acid imaging using 11C-methionine is being evaluated in patients with brain tumors and provides different information than FDG imaging.
氟代脱氧葡萄糖（FDG）与正电子发射断层扫描（PET）相结合已在脑肿瘤患者评估中显示出临床应用价值。在诊断时，FDG PET可提供有关恶性程度和患者预后的信息。治疗后，FDG PET能够评估肿瘤的持续性，确定恶性程度，监测进展，区分复发与坏死，并评估预后。其他使用PET的研究提供的信息可能具有临床实用性。肿瘤血流和血脑屏障通透性的测定可能有助于选择合适的治疗方法。使用11C-蛋氨酸的氨基酸成像正在脑肿瘤患者中进行评估，它提供了与FDG成像不同的信息。
