Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Okayama 700-8558, Japan.
Diabetes Res Clin Pract. 2010 May;88(2):171-6. doi: 10.1016/j.diabres.2010.01.012. Epub 2010 Feb 6.
This study aimed to evaluate the change of serum levels of proinflammatory molecules in patients with type 2 diabetes and clarify the involvement of these molecules in diabetic nephropathy and atherosclerosis.
Sixty-six Japanese type 2 diabetic patients (T2DM) and 39 healthy control subjects were enrolled. We assessed clinical parameters, urinary albumin excretion rate (AER), brachial-ankle pulse wave velocity (baPWV), intima media thickness (IMT) and serum levels of proinflammatory molecules.
Serum levels of IL-6, IP-10 and MCP-1 were significantly higher in T2DM than in control subjects. In T2DM, serum levels of high-sensitivity (hs) CRP, IP-10, hsTNF-alpha, VCAM-1 and E-selectin were positively correlated with AER. Serum levels of IP-10, hsTNF-alpha and VCAM-1 were positively correlated with baPWV. Serum levels of hsCRP, IL-6, IP-10 and hsTNF-alpha were positively correlated with IMT. Multiple linear regression analysis revealed that serum levels of hsTNF-alpha were independently associated with AER (beta=0.235, P=0.038) and serum levels of IP-10 were independently associated with baPWV (beta=0.209, P=0.047) and IMT (beta=0.303, P=0.032).
Our results suggest that low-grade inflammation, microinflammation, may be a common risk factor for diabetic nephropathy and atherosclerosis in Japanese type 2 diabetic patients.
本研究旨在评估 2 型糖尿病患者血清中促炎分子水平的变化，并阐明这些分子在糖尿病肾病和动脉粥样硬化中的作用。
纳入 66 例日本 2 型糖尿病患者（T2DM）和 39 例健康对照者。评估临床参数、尿白蛋白排泄率（AER）、肱踝脉搏波速度（baPWV）、内膜中层厚度（IMT）和促炎分子的血清水平。
T2DM 患者血清中 IL-6、IP-10 和 MCP-1 的水平明显高于对照组。在 T2DM 患者中，hsCRP、IP-10、hsTNF-α、VCAM-1 和 E-选择素的血清水平与 AER 呈正相关。IP-10、hsTNF-α 和 VCAM-1 的血清水平与 baPWV 呈正相关。hsCRP、IL-6、IP-10 和 hsTNF-α 的血清水平与 IMT 呈正相关。多元线性回归分析显示，hsTNF-α的血清水平与 AER 独立相关（β=0.235，P=0.038），而 IP-10 的血清水平与 baPWV（β=0.209，P=0.047）和 IMT（β=0.303，P=0.032）独立相关。
我们的结果表明，低度炎症、微炎症可能是日本 2 型糖尿病患者糖尿病肾病和动脉粥样硬化的共同危险因素。
