Departamento de Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Villa Quietud, México D.F., Mexico.
Oral Oncol. 2010 Mar;46(3):135-45. doi: 10.1016/j.oraloncology.2009.12.006. Epub 2010 Feb 6.
Important advances in Kaposi's sarcoma (KS) knowledge have been achieved, but KS is still a dilemma. It is an angioproliferative disorder classified as an intermediate neoplasm due to the absence of conventional clinical features of malignancy, but at the moment, it remains unclear if KS could be considered a reactive proliferation of endothelial cells and spindle cells, a true malignancy or both. In this review, the authors address the main epidemiological, clinical, and biological features, of the five types of KS, with emphasis on KS affecting the head and neck region. Also, a revision is done in relation with transmission, the role of saliva, and the pathogenic events associated with human herpesvirus type-8 (HHV-8). Treatment options are revised, highlighting the need for future approaches focused on targeting signaling pathways.
卡波氏肉瘤（KS）的知识取得了重要进展，但 KS 仍然是一个难题。它是一种血管增生性疾病，由于缺乏恶性肿瘤的常规临床特征，被归类为中间型肿瘤，但目前尚不清楚 KS 是否可以被认为是内皮细胞和梭形细胞的反应性增殖，一种真正的恶性肿瘤还是两者兼有。在这篇综述中，作者讨论了五种类型的 KS 的主要流行病学、临床和生物学特征，重点是影响头颈部的 KS。此外，还对传播、唾液的作用以及与人类疱疹病毒 8 型（HHV-8）相关的发病事件进行了修订。还回顾了治疗选择，强调了未来需要针对信号通路的方法。
