Duke University Medical Center, Box 103004, Durham, NC 27710, USA.
Chest. 2010 May;137(5):1195-7. doi: 10.1378/chest.10-0032. Epub 2010 Feb 5.
Historical influenza A epidemics have carried elevated rates of cardiovascular disease, including transient cardiac dysfunction. Whether such an association holds for the novel influenza A strain, pandemic 2009 influenza A(H1N1) [A(H1N1)], remains unknown. We report an index case of transient cardiac dysfunction associated with A(H1N1) infection. Next, we reviewed 123 sequential cases of patients hospitalized with pandemic A(H1N1) at a single academic medical center in the United States from April 1, 2009, through October 31, 2009. We identified that 4.9% (6/123) of patients had either new or worsened left ventricular dysfunction. These cases ranged in age from 23 to 51 years, and all had preexisting medical conditions. ICU level care was required in 83% (5/6) of the cases. Sixty-seven percent (4/6) of the cases had follow-up echocardiograms, and left ventricular function improved in all four. We conclude that potentially reversible cardiac dysfunction is a relatively common complication associated with hospitalized pandemic A(H1N1) influenza.
历史上的甲型流感大流行伴随着较高的心血管疾病发病率，包括短暂性心脏功能障碍。新型甲型流感病毒，即 2009 年甲型 H1N1 流感（A(H1N1)），是否存在这种关联尚不清楚。我们报告了一例与 A(H1N1)感染相关的短暂性心脏功能障碍的指数病例。接下来，我们回顾了 2009 年 4 月 1 日至 2009 年 10 月 31 日期间，在美国一家学术医疗中心住院的 123 例甲型 H1N1 大流行患者的连续病例。我们发现，4.9%（6/123）的患者出现新发或加重的左心室功能障碍。这些病例的年龄在 23 岁至 51 岁之间，均有既往疾病。83%（5/6）的病例需要重症监护病房治疗。67%（4/6）的病例进行了后续超声心动图检查，其中 4 例的左心室功能均有所改善。我们的结论是，与住院的甲型 H1N1 流感相关的心脏功能障碍是一种相对常见的并发症，其可能是可逆的。
