Scardina G A, Ruggieri A, Messina P
Department of Oral Science, University of Palermo, Palermo, Italy.
Indian J Dent Res. 2009 Oct-Dec;20(4):407-11. doi: 10.4103/0970-9290.59434.
Oral lichen planus is an inflammatory chronic disease with an autimmune pathogenesis and unknown etiology that affects oral mucosa, with or without the involvement of the skin and other mucous membranes. The principal histological characteristics are the degeneration of the basal cell layer and the abnormal infiltration of inflammatory cells into the subepithelial layer of connective tissue.
This study is aimed to appraise if lingual lichen planus (LLP) is sustained by alteration of the oral microcirculation and if this abnormal vascularisation increases the degeneration of basal keratinocytes and the disruption of the basement membrane.
Fifteen patients with a histological diagnosis of LLP with higher degree of degeneration of the basement membrane, fifteen LLP patients with lower degree of basement membrane (BM) degeneration and fifteen healthy patients were included in the study. The microcirculation of the left margin of the lingual mucosa of all the patients and subjects was analysed with the videocapillaroscopy. The following parameters were analyzed on each capillaroscopic image: c0 apillary loop length, loop diameter, and capillary density. The results obtained by videocapillaroscopy software were subjected to statistical analysis using Mann Whitney U-test (P < 0.001). Statistical analysis was performed using PAST software, v. 1.53.
Capillary density, loop length, and total diameter showed statistically significant differences between LLP patients with histologically lower degree of BM degeneration and healthy subjects and a meaningful significant difference between LLP patients with higher degree of BM degeneration.
A remarkable increase in capillary density was showed by videocapillaroscopic exam. The increased value of the density could be associated with angiogenesis mechanism and it could be an indicator of the evolutionary condition of LLP. Videocapillaroscopy may be useful for the evaluation of the evolution or regression of the disease.
口腔扁平苔藓是一种炎症性慢性疾病，其发病机制为自身免疫且病因不明，可累及口腔黏膜，皮肤和其他黏膜组织也可受累。主要组织学特征为基底细胞层变性以及炎症细胞异常浸润至结缔组织上皮下层。
本研究旨在评估舌扁平苔藓（LLP）是否由口腔微循环改变所维持，以及这种异常血管化是否会增加基底角质形成细胞的变性和基底膜的破坏。
本研究纳入了15例组织学诊断为基底膜变性程度较高的LLP患者、15例基底膜（BM）变性程度较低的LLP患者以及15例健康患者。使用视频毛细血管显微镜分析所有患者和受试者舌黏膜左缘的微循环。在每张毛细血管显微镜图像上分析以下参数：毛细血管袢长度、袢直径和毛细血管密度。通过视频毛细血管显微镜软件获得的结果使用Mann Whitney U检验进行统计分析（P < 0.001）。使用PAST软件v. 1.53进行统计分析。
在组织学上BM变性程度较低的LLP患者与健康受试者之间，毛细血管密度、袢长度和总直径显示出统计学上的显著差异，而在BM变性程度较高的LLP患者之间存在有意义的显著差异。
视频毛细血管显微镜检查显示毛细血管密度显著增加。密度增加的值可能与血管生成机制有关，并且可能是LLP演变情况的一个指标。视频毛细血管显微镜检查可能有助于评估疾病的进展或消退。
