González-Moles M A, González-Moles S, Ruiz-Avila I, Esteban F, Galindo-Moreno P, Rodríguez-Archilla A
Department of Oral Medicine, School of Dentistry, University of Granada, Spain.
Acta Stomatol Belg. 1996 Sep;93(3):119-23.
Oral lichen planus is an inflammatory disease with mucous and cutaneous affects caused by cellular immune reaction. Basal cell vacuolation degeneration is the result of T-cell aggression. As the clinical and histopathological alterations of OLP range from epithelial hyperplasia to epithelial atrophy and erosion, it could be that different forms of OLP finally express differences in the intensity of immune attack. The aim of the present study was to analyse the relationship between the clinical and histopathological behaviour and the intensity of the immune response to OLP by means of basal cell vacuolation and inflammatory infiltrate intensity measurement. We analysed 47 patients with OLP. Requirements for inclusion were histopathological diagnosis of OLP from an oral biopsy. Clinical and histopathological correlations were made. OLP's with an intense inflammatory infiltrate were correlated with a high grade of basal cell vacuolations (p < 0.01). A positive statistical correlation between basal cell vacuolation and epithelial atrophy (p < 0.01), and between inflammatory infiltrate intensity and epithelial atrophy (p < 0.01) were observed. An inverse statistical correlation was found when the inflammatory infiltrate intensity and the degree of basal cell vacuolation were compared with epithelial hyperplasia (p < 0.05 and p < 0.01 respectively). In the present study, OLPs with intense immune aggression frequently show epithelial atrophy and erosion on microscopic examination and vice versa.
口腔扁平苔藓是一种由细胞免疫反应引起的、累及黏膜和皮肤的炎症性疾病。基底细胞空泡变性是T细胞攻击的结果。由于口腔扁平苔藓的临床和组织病理学改变范围从上皮增生到上皮萎缩和糜烂，可能不同形式的口腔扁平苔藓最终在免疫攻击强度上表现出差异。本研究的目的是通过测量基底细胞空泡变性和炎症浸润强度，分析口腔扁平苔藓的临床和组织病理学表现与免疫反应强度之间的关系。我们分析了47例口腔扁平苔藓患者。纳入标准为经口腔活检组织病理学诊断为口腔扁平苔藓。进行了临床和组织病理学相关性分析。炎症浸润强烈的口腔扁平苔藓与基底细胞高度空泡变性相关（p < 0.01）。观察到基底细胞空泡变性与上皮萎缩之间存在正相关（p < 0.01），炎症浸润强度与上皮萎缩之间也存在正相关（p < 0.01）。当将炎症浸润强度和基底细胞空泡变性程度与上皮增生进行比较时，发现存在负相关（分别为p < 0.05和p < 0.01）。在本研究中，免疫攻击强烈的口腔扁平苔藓在显微镜检查时常常表现为上皮萎缩和糜烂，反之亦然。
