López-Jornet P, Camacho-Alonso F, Molina-Miñano F
Department of Oral Medicine, Faculty of Medicine and Odontology, University of Murcia, Hospital Morales Meseguer, Murcia, Spain.
J Eur Acad Dermatol Venereol. 2009 Jun;23(6):692-6. doi: 10.1111/j.1468-3083.2009.03160.x. Epub 2009 Feb 26.
The oral mucosa is relatively vulnerable to pathological processes, and is often affected by autoimmune and malignant diseases. The oral epithelium is normally non-homogeneous, and joins to the connective tissue through interlocking of its downward projections in the form of papillae.
This study aims to conduct a histomorphometric study of the epithelial papillae in patients with oral lichen planus (OLP).
This study was based on 100 cheek mucosa biopsies from patients with OLP (66 white reticular and 34 atrophic-erosive) (13 males and 87 females, with a mean age of 54.95 +/- 13.64 years). A histological and morphometric evaluation was made, based on imaging analysis with MIP software 4.5 for studying the papillary structure in the patients with OLP.
The mean epithelial thickness was 227.5 +/- 78.5 microm. The different papillary measures--BLS (distance from basal layer to epithelial surface), DPS (distance from dermal papilla top to epithelial surface), DPW (dermal papilla width), and DPD (interdermal papilla distance between two papillae)--yielded no statistically significant differences with respect to age, sex, smoking and clinical form. However, a significant correlation was observed in relation to papilla width and inflammatory infiltrate (P = 0.031).
The application of this imaging system is useful for measuring variations in epithelial papillary architecture.
口腔黏膜相对易受病理过程影响，常受自身免疫性疾病和恶性疾病侵害。口腔上皮通常不均一，通过乳头状向下突起与结缔组织相互嵌合相连。
本研究旨在对口腔扁平苔藓（OLP）患者的上皮乳头进行组织形态计量学研究。
本研究基于100例OLP患者的颊黏膜活检标本（66例白色网状型和34例萎缩糜烂型）（男性13例，女性87例，平均年龄54.95±13.64岁）。基于使用MIP软件4.5进行成像分析，对OLP患者的乳头结构进行组织学和形态计量学评估。
上皮平均厚度为227.5±78.5微米。不同的乳头测量值——BLS（从基底层到上皮表面的距离）、DPS（从真皮乳头顶部到上皮表面的距离）、DPW（真皮乳头宽度）和DPD（两个乳头之间的真皮乳头间距）——在年龄、性别、吸烟情况和临床类型方面无统计学显著差异。然而，观察到乳头宽度与炎症浸润之间存在显著相关性（P = 0.031）。
该成像系统的应用有助于测量上皮乳头结构的变化。
