未能从精神科患者的外周血单个核细胞中检测到博尔纳病病毒抗体和 RNA。
Failure to detect borna disease virus antibody and RNA from peripheral blood mononuclear cells of psychiatric patients.
机构信息
Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea.
出版信息
Psychiatry Investig. 2009 Dec;6(4):306-12. doi: 10.4306/pi.2009.6.4.306. Epub 2009 Nov 5.
Abstract
OBJECTIVE
Borna disease virus (BDV) is a highly neurotropic agent causing various neuropsychiatric symptoms in animals. Over the past two decades, it has been suggested that BDV might be associated with human psychiatric diseases. We aimed to investigate whether BDV is associated with psychiatric patients in Korea.
METHODS
We recruited 60 normal controls and 198 psychiatric patients (98 patients with depressive disorder, 60 with schizophrenia, and 40 with bipolar disorder). We used an indirect immunofluorescence antibody (IFA) test for the BDV antibody and a real-time reverse transcriptase polymerase chain reaction (rRT-PCR) assay for p24 and p40 RNA from peripheral blood mononuclear cells (PBMCs).
RESULTS
Neither the BDV antibody nor p24, p40 RNA was detected in controls and patients groups.
CONCLUSION
Our results suggest that BDV might not be associated with psychiatric patients in Korea.
摘要
目的
博尔纳病病毒（BDV）是一种高度嗜神经病原体，可导致动物出现各种神经精神症状。在过去的二十年中，有人提出BDV 可能与人类精神疾病有关。我们旨在调查 BDV 是否与韩国的精神科患者有关。
方法
我们招募了 60 名正常对照者和 198 名精神科患者（98 名抑郁症患者，60 名精神分裂症患者和 40 名双相情感障碍患者）。我们使用间接免疫荧光抗体（IFA）试验检测 BDV 抗体，并用实时逆转录聚合酶链反应（rRT-PCR）检测外周血单个核细胞（PBMC）中的 p24 和 p40 RNA。
结果
对照组和患者组均未检测到 BDV 抗体和 p24、p40 RNA。
结论
我们的结果表明，BDV 可能与韩国的精神科患者无关。
相似文献
1
Failure to detect borna disease virus antibody and RNA from peripheral blood mononuclear cells of psychiatric patients.未能从精神科患者的外周血单个核细胞中检测到博尔纳病病毒抗体和 RNA。
Psychiatry Investig. 2009 Dec;6(4):306-12. doi: 10.4306/pi.2009.6.4.306. Epub 2009 Nov 5.
2
Evidence for Borna disease virus infection in neuropsychiatric patients in three western China provinces.中国西部三省神经精神疾病患者中博尔纳病病毒感染的证据。
Eur J Clin Microbiol Infect Dis. 2014 Apr;33(4):621-7. doi: 10.1007/s10096-013-1996-4. Epub 2013 Oct 30.
3
Borna disease virus antibody and RNA from peripheral blood mononuclear cells of race horses and jockeys in Korea.韩国赛马和骑师外周血单个核细胞中的博尔纳病病毒抗体和 RNA。
Psychiatry Investig. 2011 Mar;8(1):58-60. doi: 10.4306/pi.2011.8.1.58. Epub 2010 Nov 27.
4
Lack of association of Borna disease virus and human T-cell leukemia virus type 1 infections with psychiatric disorders among Japanese patients.日本患者中博尔纳病病毒和1型人类T细胞白血病病毒感染与精神障碍之间无关联。
Clin Diagn Lab Immunol. 1997 Mar;4(2):189-94. doi: 10.1128/cdli.4.2.189-194.1997.
5
Immunological and PCR analyses for Borna disease virus in psychiatric patients and blood donors in Japan.日本精神病患者和献血者中博尔纳病病毒的免疫学及聚合酶链反应分析。
J Clin Microbiol. 2001 Feb;39(2):419-29. doi: 10.1128/JCM.39.2.419-429.2001.
6
Detection and sequence analysis of borna disease virus p24 RNA from peripheral blood mononuclear cells of patients with mood disorders or schizophrenia and of blood donors.对情绪障碍或精神分裂症患者以及献血者外周血单核细胞中博尔纳病病毒p24 RNA的检测与序列分析。
J Virol. 1998 Dec;72(12):10044-9. doi: 10.1128/JVI.72.12.10044-10049.1998.
7
Detection of Borna disease virus (BDV) antibodies and BDV RNA in psychiatric patients: evidence for high sequence conservation of human blood-derived BDV RNA.精神疾病患者中博尔纳病病毒（BDV）抗体和BDV RNA的检测：人血源性BDV RNA高度序列保守性的证据
J Virol. 1996 Nov;70(11):7713-24. doi: 10.1128/JVI.70.11.7713-7724.1996.
8
Detection of Borna disease virus p24 RNA in peripheral blood cells from Brazilian mood and psychotic disorder patients.巴西情绪和精神障碍患者外周血细胞中博尔纳病病毒p24 RNA的检测
J Affect Disord. 2006 Jan;90(1):43-7. doi: 10.1016/j.jad.2005.10.008. Epub 2005 Dec 1.
9
Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea.
J Neurovirol. 1999 Apr;5(2):196-9. doi: 10.3109/13550289909022002.
10
Borna disease virus and schizophrenia in Surinamese immigrants to the Netherlands.
Med Microbiol Immunol. 2000 Nov;189(2):55-7. doi: 10.1007/pl00008256.
引用本文的文献
1
Unravelling the Viral Hypothesis of Schizophrenia: A Comprehensive Review of Mechanisms and Evidence.揭开精神分裂症的病毒假说：机制与证据的全面综述
Int J Mol Sci. 2025 Aug 1;26(15):7429. doi: 10.3390/ijms26157429.
2
Involvement of virus infections and antiviral agents in schizophrenia.病毒感染及抗病毒药物与精神分裂症的关联。
Psychol Med. 2025 Mar 10;55:e73. doi: 10.1017/S0033291725000467.
3
No molecular evidence of Borna disease virus among schizophrenia and bipolar disorder patients in Iran.伊朗精神分裂症和双相情感障碍患者中未发现博尔纳病病毒的分子证据。
Iran J Microbiol. 2017 Apr;9(2):112-118.
4
Infectious and immunogenetic factors in bipolar disorder.双相障碍的感染和免疫遗传因素。
Acta Psychiatr Scand. 2017 Oct;136(4):409-423. doi: 10.1111/acps.12791. Epub 2017 Aug 20.
5
Detection of Borna Disease Virus (BDV) in Patients with First Episode of Schizophrenia.首发精神分裂症患者中博尔纳病病毒（BDV）的检测
Iran J Psychiatry. 2016 Oct;11(4):257-261.
6
The Microbial Hypothesis: Contributions of Adenovirus Infection and Metabolic Endotoxaemia to the Pathogenesis of Obesity.微生物假说：腺病毒感染和代谢性内毒素血症对肥胖发病机制的作用
Int J Chronic Dis. 2016;2016:7030795. doi: 10.1155/2016/7030795. Epub 2016 Nov 24.
7
Reconceptualizing major depressive disorder as an infectious disease.将重度抑郁症重新概念化为一种传染病。
Biol Mood Anxiety Disord. 2014 Oct 21;4:10. doi: 10.1186/2045-5380-4-10. eCollection 2014.
8
Borna disease virus (BDV) infection in psychiatric patients and healthy controls in Iran.伊朗精神病患者和健康对照人群中的博尔纳病病毒（BDV）感染
Virol J. 2014 Sep 3;11:161. doi: 10.1186/1743-422X-11-161.
9
Meta-analysis of infectious agents and depression.感染因子与抑郁症的荟萃分析。
Sci Rep. 2014 Mar 31;4:4530. doi: 10.1038/srep04530.
10
Borna disease virus antibody and RNA from peripheral blood mononuclear cells of race horses and jockeys in Korea.韩国赛马和骑师外周血单个核细胞中的博尔纳病病毒抗体和 RNA。
Psychiatry Investig. 2011 Mar;8(1):58-60. doi: 10.4306/pi.2011.8.1.58. Epub 2010 Nov 27.
本文引用的文献
1
Borna disease virus and deficit schizophrenia.
Acta Neuropsychiatr. 2003 Oct;15(5):262-5. doi: 10.1034/j.1601-5215.2003.00043.x.
2
Detection and analysis of Borna disease virus in Chinese patients with neurological disorders.中国神经系统疾病患者中博尔纳病病毒的检测与分析。
Eur J Neurol. 2009 Mar;16(3):399-403. doi: 10.1111/j.1468-1331.2008.02516.x.
3
Isotype analysis of human anti-Borna disease virus antibodies in Japanese psychiatric and general population.日本精神科患者及普通人群中人类抗博尔纳病病毒抗体的同型分析。
J Clin Virol. 2008 Nov;43(3):317-22. doi: 10.1016/j.jcv.2008.07.011. Epub 2008 Sep 10.
4
RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives.来自患有精神分裂症患者、分裂情感性障碍患者及其生物学亲属体内的博尔纳病病毒RNA。
J Clin Lab Anal. 2008;22(4):314-20. doi: 10.1002/jcla.20261.
5
Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus.持续性博尔纳病病毒（BDV）感染在海马颗粒细胞出现可检测到的损失之前就激活了小胶质细胞。
J Neuroinflammation. 2008 May 19;5:16. doi: 10.1186/1742-2094-5-16.
6
Borna disease virus infection impairs synaptic plasticity.博尔纳病病毒感染会损害突触可塑性。
J Virol. 2007 Aug;81(16):8833-7. doi: 10.1128/JVI.00612-07. Epub 2007 Jun 6.
7
Development of a real-time RT-PCR assay for improved detection of Borna disease virus.一种用于改进博尔纳病病毒检测的实时逆转录聚合酶链反应检测方法的开发。
J Virol Methods. 2007 Jul;143(1):1-10. doi: 10.1016/j.jviromet.2007.01.034. Epub 2007 Mar 21.
8
Meta-analysis of putative human bornavirus sequences fails to provide evidence implicating Borna disease virus in mental illness.对假定的人类博尔纳病毒序列进行的荟萃分析未能提供将博尔纳病病毒与精神疾病相关联的证据。
Rev Med Virol. 2007 May-Jun;17(3):181-203. doi: 10.1002/rmv.530.
9
Serological evidence for Borna disease virus infection in humans, wild rodents and other vertebrates in Finland.芬兰人类、野生啮齿动物及其他脊椎动物感染博尔纳病病毒的血清学证据。
J Clin Virol. 2007 Jan;38(1):64-9. doi: 10.1016/j.jcv.2006.10.003. Epub 2006 Nov 28.
10
Reverse transcription real-time PCR assays for detection and quantification of Borna disease virus in diseased hosts.
Mol Cell Probes. 2007 Feb;21(1):47-55. doi: 10.1016/j.mcp.2006.08.001. Epub 2006 Aug 30.
Zotero 插件