30种化学物质的啮齿动物致癌性预测
Prediction of rodent carcinogenicity for 30 chemicals.
作者信息
Ashby J
机构信息
Zeneca Central Toxicology Laboratory, Cheshire, United Kingdom.
出版信息
Environ Health Perspect. 1996 Oct;104 Suppl 5(Suppl 5):1101-4. doi: 10.1289/ehp.96104s51101.
Abstract
Predictions of carcinogenic activity are made for 30 chemicals currently being assessed for rodent carcinogenicity by the U.S. National Toxicology Program. The predictions are based upon the chemical structure, the anticipated or reported mutagenicity, and the reported sub-chronic toxicity of each chemical. It is predicted that 13 chemicals will be noncarcinogenic to rodents, that 7 will be genotoxic carcinogens, and that 10 may show some evidence of presumed nongenotoxic rodent carcinogenesis.
摘要
美国国家毒理学计划目前正在对30种化学物质进行啮齿动物致癌性评估，并对其致癌活性进行预测。这些预测基于每种化学物质的化学结构、预期或已报道的致突变性以及已报道的亚慢性毒性。预计有13种化学物质对啮齿动物无致癌性，7种为遗传毒性致癌物，10种可能显示出一些假定的非遗传毒性啮齿动物致癌作用的证据。
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