铜催化的酚芳基化反应：空间位阻较大的芳基和杂芳基二芳基醚的合成。
Cu-catalyzed arylation of phenols: synthesis of sterically hindered and heteroaryl diaryl ethers.
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
出版信息
J Org Chem. 2010 Mar 5;75(5):1791-4. doi: 10.1021/jo9026935.
Abstract
Cu-catalyzed O-arylation of phenols with aryl iodides and bromides can be performed under mild condition in DMSO/K(3)PO(4) with use of picolinic acid as the ligand for copper. This method tolerates a variety of functional groups and is effective in the synthesis of hindered diaryl ethers and heteroaryl ethers.
摘要
在 DMSO/K3PO4中，使用吡啶甲酸作为铜的配体，在温和条件下，酚类化合物可以与芳基碘化物和溴化物进行铜催化的 O-芳基化反应。该方法对多种官能团具有耐受性，并且在受阻二芳基醚和杂芳基醚的合成中非常有效。
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