Blackburn Ninian J
Department of Science and Engineering, School of Medicine, Oregon Health & Sciences University, 20000 NW Walker Road, Beaverton, OR 97006-8291, USA.
Chem Biol. 2010 Jan 29;17(1):8-9. doi: 10.1016/j.chembiol.2010.01.004.
A recent study by Thomas O'Halloran and his group at Northwestern University (Avarez et al. Sciencexpress, www.scienceexpress.org, 26 November 2009) has provided insights into how tetrathiomolybdate inhibits copper-trafficking proteins through metal cluster formation. The broader context of the work provides an attractive explanation of the long recognized but poorly understood antagonistic effects of Mo and Cu in living organisms.
西北大学的托马斯·奥哈洛伦及其团队最近进行的一项研究（阿瓦雷兹等人，《科学快讯》，www.scienceexpress.org，2009年11月26日）揭示了四硫代钼酸盐如何通过形成金属簇来抑制铜转运蛋白。这项工作的更广泛背景为钼和铜在生物体中早已为人所知但却了解甚少的拮抗作用提供了一个有吸引力的解释。
