Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55455, USA.
Cancer Epidemiol Biomarkers Prev. 2010 Feb;19(2):435-42. doi: 10.1158/1055-9965.EPI-09-0976.
Several epidemiologic studies have shown inverse associations between use of nonsteroidal anti-inflammatory drugs (NSAID) and incident ovarian cancer, but the results are inconsistent. There have been only a few studies examining possible links between NSAIDs and endometrial cancer risk. We investigated associations between use of NSAIDs and incident ovarian and endometrial cancers in a prospective cohort of about 20,000 women with ages from 58 to 76 years in 1992. Participants were asked how often they used aspirin and nonaspirin NSAIDs. Over 15 years, 311 endometrial and 167 ovarian incident malignancies were identified. Multivariate-adjusted hazard ratios were estimated using Cox proportional regression.
Compared with women who reported no use of aspirin, the relative risks for ovarian cancer for those who used aspirin <2, 2 to 5 times, and > or = 6 times per week were 0.83, 0.77, and 0.61, respectively (P trend = 0.04). We did not observe any association between nonaspirin NSAIDs use and ovarian cancer risk. Neither did we find associations between aspirin or nonaspirin NSAIDs use and risk for endometrial cancer.
Our results suggest a possible inverse association between frequency of aspirin use and risk for ovarian cancer.
多项流行病学研究表明，使用非甾体抗炎药（NSAID）与卵巢癌的发病风险呈负相关，但结果并不一致。仅有少数研究探讨了 NSAIDs 与子宫内膜癌风险之间的可能联系。我们对 1992 年年龄在 58 至 76 岁的近 20000 名女性进行了一项前瞻性队列研究，调查了 NSAIDs 使用与卵巢和子宫内膜癌发病风险之间的关联。研究对象被问及她们使用阿司匹林和非阿司匹林 NSAIDs 的频率。在 15 年的时间里，共发现 311 例子宫内膜和 167 例卵巢癌新发病例。采用 Cox 比例风险回归模型估计多变量校正后的危险比。
与未使用阿司匹林的女性相比，每周使用阿司匹林<2 次、2-5 次和≥6 次的女性卵巢癌的相对危险度分别为 0.83、0.77 和 0.61（P 趋势=0.04）。我们未观察到非阿司匹林 NSAIDs 使用与卵巢癌风险之间存在关联。我们也未发现阿司匹林或非阿司匹林 NSAIDs 使用与子宫内膜癌风险之间存在关联。
我们的研究结果表明，阿司匹林使用频率与卵巢癌风险之间可能存在负相关关系。
