Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA.
Hum Brain Mapp. 2010 Nov;31(11):1627-42. doi: 10.1002/hbm.20963.
Human activities often involve hand-motor responses following external auditory-verbal commands. It has been believed that hand movements are predominantly driven by the contralateral primary sensorimotor cortex, whereas auditory-verbal information is processed in both superior temporal gyri. It remains unknown whether cortical activation in the superior temporal gyrus during an auditory-motor task is affected by laterality of hand-motor responses. Here, event-related γ-oscillations were intracranially recorded as quantitative measures of cortical activation; we determined how cortical structures were activated by auditory-cued movement using each hand in 15 patients with focal epilepsy. Auditory-verbal stimuli elicited augmentation of γ-oscillations in a posterior portion of the superior temporal gyrus, whereas hand-motor responses elicited γ-augmentation in the pre- and postcentral gyri. The magnitudes of such γ-augmentation in the superior temporal, precentral, and postcentral gyri were significantly larger when the hand contralateral to the recorded hemisphere was required to be used for motor responses, compared with when the ipsilateral hand was. The superior temporal gyrus in each hemisphere might play a greater pivotal role when the contralateral hand needs to be used for motor responses, compared with when the ipsilateral hand does.
人类活动通常涉及对外来听觉-言语命令的手部运动反应。人们普遍认为手部运动主要由对侧初级感觉运动皮层驱动，而听觉言语信息则在两个颞上回中处理。目前尚不清楚在听觉运动任务中，颞上回的皮质激活是否受手部运动反应的偏侧性影响。在这里，我们使用颅内记录的事件相关 γ-振荡作为皮质激活的定量测量；我们确定了在 15 名局灶性癫痫患者中，使用每只手时听觉提示运动如何激活皮质结构。听觉言语刺激引起颞上回后部 γ-振荡的增强，而手部运动反应则引起中央前回和中央后回的 γ-增强。当需要使用记录半球对侧的手进行运动反应时，与使用同侧手相比，颞上回、中央前回和中央后回的γ-增强幅度明显更大。与使用同侧手相比，当需要使用对侧手进行运动反应时，每个半球的颞上回可能发挥更大的关键作用。
