Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit Medical Center, 3901 Beaubien Street, Detroit, MI 48201, USA.
Epilepsy Behav. 2010 May;18(1-2):116-8. doi: 10.1016/j.yebeh.2010.03.008. Epub 2010 May 6.
Recent studies have suggested that cortical activation can be measured using event-related augmentation of gamma oscillations in humans. We determined how commonly and differentially gamma oscillations (50-150Hz) were modulated by three distinct word-association tasks during extraoperative electrocorticography monitoring in a patient with focal epilepsy who underwent epilepsy surgery. He was auditorily presented names of common foods (e.g., apple) during each task. He was instructed to overtly verbalize the color (e.g., red) of each given food during the first association task, the taste (e.g., sweet) during the second task, and the texture (e.g., crunchy) during the third task. All three word-association tasks commonly elicited significant augmentation of gamma oscillations in the superior temporal gyrus, the middle temporal gyrus, and the inferior frontal gyrus, as well as the pre- and postcentral gyri. The food-texture association task specifically elicited significant gamma augmentation in the supramarginal gyrus. This preliminary study generated the hypothesis that word-association tasks may supplement functional language mapping using electrical stimulation. Differential gamma augmentation in the supramarginal gyrus might be attributed to a larger workload required in the food-texture association task compared with the remaining two tasks.
最近的研究表明，皮质激活可以通过人类伽马振荡的事件相关增强来测量。我们在一名接受局灶性癫痫手术的患者的手术期间的皮质电图监测中，确定了三种不同的联想任务如何共同且不同地调节伽马振荡（50-150Hz）。在每个任务中，他都通过听觉听到常见食物的名称（例如，苹果）。他被指示在第一个联想任务中说出每个给定食物的颜色（例如，红色），在第二个任务中说出味道（例如，甜），在第三个任务中说出质地（例如，脆脆）。所有三种联想任务都共同引起了颞上回、中颞回和下额回以及中央前回和中央后回的伽马振荡显著增强。食物质地联想任务特别引起了缘上回的伽马增强。这项初步研究提出了一个假设，即联想任务可能会补充使用电刺激的功能语言映射。缘上回的伽马增强差异可能归因于食物质地联想任务比其余两个任务需要更大的工作量。
