Boĭko E V, Pozniak A L, Aliab'ev M V, Ageev V S, Prokhvatilov G I, Tipikin V P, Kharitonova N N
Vestn Oftalmol. 2009 Nov-Dec;125(6):22-5.
Thirty-four patients with foci of chronic rhino- or odontogenic infection were examined. All the patients underwent physical examination, biochemical blood analysis, immunological test for immunoglobulins A, G, and M, circulating immune complexes, leukocyte migration inhibition test with phytohemagglutinin, Con A, with antigens of the retina, vitreous body, iris, and lens, scrapes from the dentogingival pocket, conjunctival and nasal cavities for Chlamydia, followed by direct immunofluorescence, polymerase chain reaction, and culture. Chronic rhino- or odontogenic infection foci impair local ocular immunity in ophthalmologically healthy patients. The foci of chronic rhinogenic infection cause more pronounced changes in systemic and local ocular immunity than those of chronic odontogenic infection. In half the patients with chronic rhino- or odontogenic infection foci, Chlamydia are detectable in the oral, nasal, and ocular mucosae, which suggests that there is generalized infection and there is a need for complex sanitation of the body. Isolated local treatment for Chlamydia infection is not promising.
对34例患有慢性鼻源性或牙源性感染病灶的患者进行了检查。所有患者均接受了体格检查、血液生化分析、免疫球蛋白A、G和M、循环免疫复合物的免疫学检测、用植物血凝素、刀豆蛋白A以及视网膜、玻璃体、虹膜和晶状体抗原进行的白细胞迁移抑制试验、取自牙龈袋、结膜和鼻腔的刮片以检测衣原体，随后进行直接免疫荧光、聚合酶链反应和培养。慢性鼻源性或牙源性感染病灶会损害眼科健康患者的局部眼部免疫力。与慢性牙源性感染病灶相比，慢性鼻源性感染病灶会导致全身和局部眼部免疫力发生更明显的变化。在一半患有慢性鼻源性或牙源性感染病灶的患者中，在口腔、鼻腔和眼部黏膜中可检测到衣原体，这表明存在全身性感染，需要对身体进行综合卫生处理。对衣原体感染进行单独的局部治疗没有前景。
