黑米（Oryza sativa L. Japonica）花色苷提取物对大鼠慢性酒精性肝损伤的影响。

Effect of anthocyanin-rich extract from black rice (Oryza sativa L. Japonica) on chronically alcohol-induced liver damage in rats.

机构信息

Institute of Crop Science, Chinese Academy of Agricultural Sciences No. 80 South Xueyuan Road, Haidian District, Beijing100081, P. R. China.

出版信息

J Agric Food Chem. 2010 Mar 10;58(5):3191-6. doi: 10.1021/jf904407x.

DOI:10.1021/jf904407x

PMID:20143824

Abstract

The study evaluated the protective effect of anthocyanin-rich extract from black rice (AEBR) on chronic ethanol-induced biochemical changes in male Wistar rats. Administration of ethanol (3.7 g/kg/day) to Wistar rats for 45 days induced liver damage with a significant increase (P < 0.05) of aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyl transferase (GGT) in the serum and the hepatic malondialdehyde (MDA) level. In contrast, administration of AEBR (500 mg/kg) along with alcohol significantly (P < 0.01) decreased the activities of liver enzymes (AST, ALT and GGT) in serum, the MDA levels and the concentrations of serum and hepatic triglyceride (TG) and total cholesterol (TCH). Rats treated with AEBR showed a better profile of the antioxidant system with normal glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and glutathione S-transferase (GST) activities. All these results were accompanied by histological observations in liver. The results demonstrate that AEBR has a beneficial effect in reducing the adverse effect of alcohol.

摘要

该研究评估了黑米中富含的花色苷提取物（AEBR）对慢性乙醇诱导的雄性 Wistar 大鼠生化变化的保护作用。给予 Wistar 大鼠 3.7 g/kg/天的乙醇 45 天，导致肝损伤，血清中天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、γ-谷氨酰转移酶（GGT）活性显著增加（P < 0.05），肝组织丙二醛（MDA）水平升高。相比之下，同时给予 AEBR（500 mg/kg）可显著降低血清中肝酶（AST、ALT 和 GGT）、MDA 水平以及血清和肝组织甘油三酯（TG）和总胆固醇（TCH）的浓度（P < 0.01）。用 AEBR 处理的大鼠表现出更好的抗氧化系统特征，谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）和谷胱甘肽 S-转移酶（GST）活性正常。所有这些结果都伴有肝组织学观察。结果表明，AEBR 具有减轻酒精不良作用的有益效果。