Pari L, Karthikesan K
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamil Nadu, India.
Fundam Clin Pharmacol. 2007 Aug;21(4):355-61. doi: 10.1111/j.1472-8206.2007.00505.x.
Caffeic acid is a well-known phenolic compound mainly present in plants. In this study, caffeic acid was evaluated for its protective effect against chronic ethanol-induced biochemical changes in male Wistar rats. Administration of ethanol (7.9 g/kg/day) for 45 days induced liver and kidney damage as manifested by a significant increase in the levels of serum hepatic and renal markers namely aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), bilirubin, urea, creatinine, and a significant decrease in creatinine clearance and levels of hemoglobin. Plasma thiobarbituric acid-reactive substances and hydroperoxide were significantly elevated where as the levels of nonenzymic antioxidants [reduced glutathione, vitamin E and vitamin C] were significantly decreased in alcohol-intoxicated rats. Administration of caffeic acid along with alcohol significantly decreased the serum levels of liver and kidney markers to near-normal levels. In addition, administration of caffeic acid significantly decreased the levels of lipid peroxidation markers while the levels of antioxidants were significantly increased in circulation of alcohol-fed rats. All these results were accompanied by histological observations in liver. The results demonstrate that caffeic acid has a beneficial effect in reducing the adverse effect of alcohol.
咖啡酸是一种主要存在于植物中的著名酚类化合物。在本研究中，评估了咖啡酸对雄性Wistar大鼠慢性乙醇诱导的生化变化的保护作用。给予乙醇（7.9克/千克/天）45天可导致肝和肾损伤，表现为血清肝和肾标志物水平显著升高，即天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、碱性磷酸酶（ALP）、γ-谷氨酰转移酶（GGT）、胆红素、尿素、肌酐，同时肌酐清除率和血红蛋白水平显著降低。乙醇中毒大鼠的血浆硫代巴比妥酸反应性物质和过氧化氢显著升高，而非酶抗氧化剂[还原型谷胱甘肽、维生素E和维生素C]水平显著降低。与乙醇同时给予咖啡酸可使肝和肾标志物的血清水平显著降低至接近正常水平。此外，给予咖啡酸可显著降低脂质过氧化标志物水平，同时在喂食乙醇的大鼠循环中抗氧化剂水平显著升高。所有这些结果都伴有肝脏的组织学观察。结果表明，咖啡酸在减轻乙醇的不良影响方面具有有益作用。
