Unitat d'Anatomia Patològica, Universitat Rovira i Virgili, Reus, Spain.
Med Mycol. 2014 Jan;52(1):29-35. doi: 10.3109/13693786.2013.797610.
Acremonium is an emerging fungal pathogen causing severe infections. We evaluated the virulence of three clinically relevant species within the genus, i.e., Acremonium kiliense (currently Sarocladium kiliense), Acremonium sclerotigenum-A. egyptiacum complex and Acremonium implicatum in a murine model of disseminated infection. Both immunocompetent and immunosuppresssed mice were infected with two inocula concentrations (2 × 10(6) and 2 × 10(8) conidia/animal) of two strains of each species. Tissue burden, mortality rate, histopathology and levels of (1→3)-β-D-glucan were used as virulence markers. None of the species of Acremonium tested was able to cause infection in immunocompetent mice. Conversely, severe infections were produced in immunocompromised mice, the spleen being the most affected organ. In general, the virulence of the Acremonium species tested was low, S. kiliense being the most virulent species.
节菱孢属是一种新兴的真菌病原体，可引起严重感染。我们在播散性感染的小鼠模型中评估了种内三种具有临床相关性的物种，即尖孢节菱孢（现称拟金龟子尖孢镰孢）、硬皮镰刀菌-埃及拟节菱孢复合种和拟节菱孢的毒力。用两种浓度（2×10(6)和 2×10(8)个分生孢子/动物）的两种菌株感染免疫功能正常和免疫抑制的小鼠。组织负荷、死亡率、组织病理学和（1→3）-β-D-葡聚糖水平用作毒力标志物。所测试的节菱孢属的任何一种物种均不能在免疫功能正常的小鼠中引起感染。相反，在免疫功能低下的小鼠中会产生严重感染，脾脏是受影响最严重的器官。通常，测试的节菱孢属物种的毒力较低，其中尖孢节菱孢的毒力最强。
