Terzic Milan M, Dotlic Jelena, Maricic Sanja, Mihailovic Tihomir, Tosic-Race Bratislava
Department of Obstetrics and Gynecology, School of Medicine, University of Belgrade, Belgrade, Serbia.
J Obstet Gynaecol Res. 2009 Dec;35(6):1091-5. doi: 10.1111/j.1447-0756.2009.001059.x.
Menopause is associated with adverse metabolic changes, especially in plasma lipoprotein and cholesterol levels. Estrogens have beneficial effects on lipid metabolism. Phytoestrogens are plant substances that are structurally and functionally similar to 17beta-estradiol and are capable of producing estrogenic effects. The goal of the present study was to estimate the effects of red clover-derived isoflavones on serum lipid levels in postmenopausal women.
The study comprised 40 healthy postmenopausal women with an average age of 56 years. The women were divided into two groups: 22 were allocated to a red clover-derived isoflavone medication group, and 18 were allocated to a non-medication group. Total blood cholesterol, cholesterol fractions and triglycerides in the women of both groups were investigated before treatment and at 4-month intervals over the following 12 months.
Both total serum cholesterol and low-density lipoprotein (LDL) cholesterol levels, as well as triglyceride levels, were decreased significantly in the group receiving phytoestrogens. However, high-density lipoprotein (HDL) cholesterol showed a significant increase.
Red clover phytoestrogen supplementation in postmenopausal women had favorable metabolic effects on serum lipids. Furthermore, red clover phytoestrogens have no side-effects and can be considered safe.
绝经与不良代谢变化相关，尤其是血浆脂蛋白和胆固醇水平。雌激素对脂质代谢有有益作用。植物雌激素是在结构和功能上与17β-雌二醇相似且能够产生雌激素效应的植物物质。本研究的目的是评估红车轴草衍生的异黄酮对绝经后女性血清脂质水平的影响。
该研究纳入了40名平均年龄为56岁的健康绝经后女性。这些女性被分为两组：22名被分配到红车轴草衍生的异黄酮用药组，18名被分配到非用药组。在治疗前以及接下来的12个月中每隔4个月对两组女性的总血胆固醇、胆固醇组分和甘油三酯进行调查。
接受植物雌激素的组中，血清总胆固醇和低密度脂蛋白（LDL）胆固醇水平以及甘油三酯水平均显著降低。然而，高密度脂蛋白（HDL）胆固醇显著升高。
绝经后女性补充红车轴草植物雌激素对血清脂质有良好的代谢作用。此外，红车轴草植物雌激素无副作用，可被认为是安全的。
