Lipovac Markus, Chedraui Peter, Gruenhut Christine, Gocan Anca, Kurz Christine, Neuber Benedikt, Imhof Martin
Division of Obstetrics and Gynecology, General Public Teaching Hospital Korneuburg, 2100 Korneuburg, Austria.
Obstet Gynecol Int. 2011;2011:949302. doi: 10.1155/2011/949302. Epub 2011 Nov 1.
Objective. Evaluate in postmenopausal women the effect of red clover extract (RCE) isoflavones over subjective status of skin, appendages, and several mucosal sites. Method. Postmenopausal women (n = 109) were randomly assigned to receive either two daily capsules of the active compound (80 mg RCE, Group A) or placebo of equal appearance (Group B) for a 90-day period. After a washout period of 7 days, medication was crossed over and taken for 90 days more. Subjective improvement of skin, appendages, and several mucosal site status was assessed for each studied group at 90 and 187 days using a visual analogue scale (VAS). In addition, libido, tiredness, and urinary, sleep, and mood complaints were also evaluated. Results. Women after RCE intervention (both groups) reported better subjective improvement of scalp hair and skin status, libido, mood, sleep, and tiredness. Improvement of urinary complaints, nail, body hair, and mucosa (oral, nasal, and ocular) status did not differ between treatment phases (intra- and intergroup). Overall satisfaction with treatment was reported higher after RCE intervention (both groups) as compared to placebo. Conclusion. RCE supplementation exerted a subject improvement of scalp hair and skin status as well as libido, mood, sleep, and tiredness in postmenopausal women.
目的。评估红三叶草提取物（RCE）异黄酮对绝经后女性皮肤、附属器及多个黏膜部位主观状态的影响。方法。绝经后女性（n = 109）被随机分为两组，一组每天服用两粒活性化合物胶囊（80毫克RCE，A组），另一组服用外观相同的安慰剂（B组），为期90天。经过7天的洗脱期后，两组交叉用药，再服用90天。在第90天和187天，使用视觉模拟量表（VAS）对每个研究组的皮肤、附属器及多个黏膜部位的主观改善情况进行评估。此外，还对性欲、疲劳以及泌尿、睡眠和情绪方面的不适进行了评估。结果。RCE干预后的女性（两组）在头皮头发和皮肤状态、性欲、情绪、睡眠和疲劳方面的主观改善情况更好。在治疗阶段（组内和组间），泌尿不适、指甲、体毛和黏膜（口腔、鼻腔和眼部）状态的改善情况没有差异。与安慰剂相比，RCE干预后（两组）对治疗的总体满意度更高。结论。补充RCE可使绝经后女性的头皮头发和皮肤状态以及性欲、情绪、睡眠和疲劳得到主观改善。
