Department of Biological Sciences, Cork Institute of Technology, Bishopstown, Cork, Ireland.
Epidemiol Infect. 2010 May;138(5):673-6. doi: 10.1017/S0950268810000191. Epub 2010 Feb 10.
One thousand adults aged between 18 and 35 years were investigated for nasal colonization with community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). Each volunteer completed a questionnaire to assess the presence or absence of risk factors for hospital-acquired MRSA (HA-MRSA) carriage. All MRSA isolated were characterized by microbiological and molecular methods. A S. aureus carriage rate of 22% and a MRSA carriage rate of 0.7% were observed. Analysis of the questionnaires revealed 121 individuals with HA-MRSA risk factors. Subsequently two MRSA infections with associated risk factors were excluded from calculation of the true carriage rate and an adjusted rate of 0.57% (5/879) was established. All seven MRSA isolates expressed the genotypic profile ST22-MRSA-IV, were PVL negative, agr type 1, and differed only by their antimicrobial susceptibility patterns. ST22-MRSA-IV (EMRSA-15) has shown worldwide spread in the hospital setting but has not been previously documented in isolation in the community.
对 1000 名年龄在 18 至 35 岁之间的成年人进行了社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA）鼻腔定植调查。每位志愿者都填写了一份问卷，以评估是否存在医院获得性耐甲氧西林金黄色葡萄球菌（HA-MRSA）定植的危险因素。所有分离的 MRSA 均采用微生物学和分子方法进行了特征描述。观察到金黄色葡萄球菌定植率为 22%，MRSA 定植率为 0.7%。对问卷的分析显示，有 121 名个体存在 HA-MRSA 危险因素。随后，将与危险因素相关的两例 MRSA 感染排除在定植率计算之外，建立了调整后的定植率为 0.57%（5/879）。所有 7 株 MRSA 分离株均表达 ST22-MRSA-IV 基因型谱，均为 PVL 阴性、agr 型 1，仅在抗菌药物敏感性模式上存在差异。ST22-MRSA-IV（EMRSA-15）已在全球范围内在医院环境中传播，但以前并未在社区中孤立分离到。
