Kilpatrick Eric S
Department of Clinical Biochemistry, Hull Royal Infirmary, Hull, United Kingdom.
J Diabetes Sci Technol. 2009 Jul 1;3(4):649-55. doi: 10.1177/193229680900300405.
There is now unequivocal evidence that improving glycemic control in both type 1 and type 2 diabetes reduces the likelihood of developing the micro- and macrovascular complications of the disease. However, it is still unclear whether a patient with very variable glucose is at any different a risk of these problems than someone who has the same mean glucose but much more stable glycemia. This article reviews the evidence that exists to both support and refute the claim that increased glucose variability should be regarded as an independent risk factor for the development of diabetic vascular disease.
现在有明确的证据表明，改善1型和2型糖尿病患者的血糖控制可降低发生该疾病微血管和大血管并发症的可能性。然而，血糖波动很大的患者与平均血糖相同但血糖更稳定的患者相比，发生这些问题的风险是否存在差异仍不清楚。本文综述了支持和反驳以下观点的现有证据：血糖变异性增加应被视为糖尿病血管疾病发生的独立危险因素。
