Herman William H
University of Michigan, Ann Arbor, Michigan 48109-5354, USA.
J Diabetes Sci Technol. 2009 Jul 1;3(4):656-60. doi: 10.1177/193229680900300406.
Hemoglobin A1c (HbA1c) is widely used as an index of mean glycemia, a measure of risk for the development of diabetes complications, and a measure of the quality of diabetes care. Emerging literature suggests that, although HbA1c levels change little over time within persons without diabetes, they vary considerably among individuals, suggesting that factors other than glycemia may impact HbA1c. Racial and ethnic differences in HbA1c have been described that do not appear to be explained by differences in glycemia. It is imperative that the nonglycemic factors that affect HbA1c be more clearly defined. Even more important, it must be determined whether differences among individuals or groups correlate with susceptibility to complications or merely reflect variation in hemoglobin glycation.
糖化血红蛋白（HbA1c）被广泛用作平均血糖水平的指标、糖尿病并发症发生风险的衡量标准以及糖尿病护理质量的衡量标准。新出现的文献表明，虽然在无糖尿病的个体中，HbA1c水平随时间变化不大，但个体之间差异很大，这表明除血糖外的其他因素可能会影响HbA1c。已经描述了HbA1c的种族和民族差异，这些差异似乎无法用血糖差异来解释。必须更明确地界定影响HbA1c的非血糖因素。更重要的是，必须确定个体或群体之间的差异是否与并发症易感性相关，还是仅仅反映血红蛋白糖化的变化。
