Asakura Toshinari, Jensen Klaus H
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan.
J Diabetes Sci Technol. 2009 Mar 1;3(2):312-9. doi: 10.1177/193229680900300212.
The intuitiveness, instruction time, and handling of the Levemir (insulin detemir) FlexPen and the Lantus OptiClik pen (with insulin glargine) were investigated.
This randomized open-label crossover study involved two groups of insulin-device-naive Japanese patients with type 2 diabetes [mean (SD) age 61.9 +/- 12.3 years, 57% male]. Patients were evaluated on the ease-of-use of each insulin pen without instruction [intuitiveness group (n = 32)], or with instruction [instruction time group (n = 29)]. Patient preferences for the respective devices were assessed by questionnaire.
FlexPen required significantly less instruction time (p < .001) and was objectively more intuitive to use (p < .001) than OptiClik. Nevertheless, few patients in the intuitiveness group felt confident injecting either pen prior to instruction (FlexPen, 31%; OptiClik, 16%). No patients in the instruction time group found FlexPen difficult to learn, whereas 45% of patients found OptiClik difficult or very difficult to learn. FlexPen was rated simpler to use (77% versus 12%; p < .001), easier to inject (67% versus 13%; p < .001), and more convenient (71% versus 12%; p < .001) compared with OptiClik. More patients would trust FlexPen to deliver insulin injections (p < .01) and would prefer to use FlexPen compared with OptiClik (82% versus 13%; p < .001).
FlexPen was faster to teach, simpler to use, and more trusted by patients compared with OptiClik. Mean injection time was significantly shorter for FlexPen than OptiClik, with or without instruction. This study highlights not only how easy it is for patients to learn to use FlexPen, but also how easily health care providers can teach patients to use it.
对来得时(胰岛素 detemir)预填充注射笔和甘李药业的畅充胰岛素笔(含胰岛素 glargine)的直观性、操作说明时间及使用情况进行了研究。
这项随机开放标签交叉研究纳入了两组之前未使用过胰岛素笔的日本 2 型糖尿病患者[平均(标准差)年龄 61.9±12.3 岁,57%为男性]。在无操作说明的情况下评估患者对每种胰岛素笔的易用性[直观性组(n = 32)],或在有操作说明的情况下评估[操作说明时间组(n = 29)]。通过问卷调查评估患者对各设备的偏好。
与畅充胰岛素笔相比,来得时预填充注射笔所需的操作说明时间显著更少(p <.001),且在客观上使用起来更直观(p <.001)。然而,在直观性组中,很少有患者在接受操作说明前对使用这两种笔进行注射有信心(来得时预填充注射笔为 31%;畅充胰岛素笔为 16%)。操作说明时间组中没有患者觉得来得时预填充注射笔难学,而 45%的患者觉得畅充胰岛素笔难学或非常难学。与畅充胰岛素笔相比,来得时预填充注射笔被评为使用更简单(77%对 12%;p <.001)、注射更容易(67%对 13%;p <.001)且更方便(71%对 12%;p <.001)。更多患者会信赖来得时预填充注射笔进行胰岛素注射(p <.01),且与畅充胰岛素笔相比,更多患者更愿意使用来得时预填充注射笔(82%对 13%;p <.001)。
与畅充胰岛素笔相比,来得时预填充注射笔教学更快、使用更简单且更受患者信赖。无论有无操作说明,来得时预填充注射笔的平均注射时间均显著短于畅充胰岛素笔。这项研究不仅凸显了患者学习使用来得时预填充注射笔有多容易,也凸显了医护人员教导患者使用它有多容易。