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Safe and Effective Use of the Once Weekly Dulaglutide Single-Dose Pen in Injection-Naïve Patients With Type 2 Diabetes.在初治2型糖尿病患者中安全有效地使用度拉糖肽单剂量笔(每周一次)
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Usability of devices for self-injection: results of a formative study on a new disposable pen injector.自我注射设备的可用性:一项关于新型一次性笔式注射器的形成性研究结果
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本文引用的文献

1
Differences in the dose accuracy of insulin pens.胰岛素笔剂量准确性的差异。
J Diabetes Sci Technol. 2008 May;2(3):478-81. doi: 10.1177/193229680800200318.
2
Intuitiveness, instruction time, and patient acceptance of a prefilled insulin delivery device and a reusable insulin delivery device in a randomized, open-label, crossover handling study in patients with type 2 diabetes.在一项针对2型糖尿病患者的随机、开放标签、交叉操作研究中,预填充胰岛素输送装置和可重复使用胰岛素输送装置的直观性、指导时间及患者接受度。
Clin Ther. 2008 Dec;30(12):2252-62. doi: 10.1016/j.clinthera.2008.12.004.
3
Dosing accuracy of two insulin pre-filled pens.两种胰岛素预填充笔的给药准确性。
Curr Med Res Opin. 2008 May;24(5):1429-34. doi: 10.1185/030079908x297394. Epub 2008 Apr 8.
4
Health outcomes and economic impact of therapy conversion to a biphasic insulin analog pen among privately insured patients with type 2 diabetes mellitus.2型糖尿病私人参保患者转换为双相胰岛素类似物笔治疗的健康结局和经济影响。
Pharmacotherapy. 2007 Jul;27(7):948-62. doi: 10.1592/phco.27.7.948.
5
Standards of medical care in diabetes--2007.《2007年糖尿病医疗护理标准》
Diabetes Care. 2007 Jan;30 Suppl 1:S4-S41. doi: 10.2337/dc07-S004.
6
Medication adherence and the associated health-economic impact among patients with type 2 diabetes mellitus converting to insulin pen therapy: an analysis of third-party managed care claims data.2型糖尿病患者转换为胰岛素笔治疗后的药物依从性及相关健康经济影响:基于第三方管理式医疗理赔数据的分析
Clin Ther. 2006 Oct;28(10):1712-25; discussion 1710-1. doi: 10.1016/j.clinthera.2006.10.004.
7
FlexPen: addressing issues of confidence and convenience in insulin delivery.优伴笔:解决胰岛素注射中的信心与便利性问题。
Clin Ther. 2005;27 Suppl B:S89-100. doi: 10.1016/j.clinthera.2005.11.019.
8
Resistance to insulin therapy among patients and providers: results of the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) study.患者及医疗服务提供者对胰岛素治疗的抗拒:跨国糖尿病态度、愿望与需求(DAWN)研究结果
Diabetes Care. 2005 Nov;28(11):2673-9. doi: 10.2337/diacare.28.11.2673.
9
Psychosocial problems and barriers to improved diabetes management: results of the Cross-National Diabetes Attitudes, Wishes and Needs (DAWN) Study.心理社会问题及改善糖尿病管理的障碍:跨国糖尿病态度、愿望与需求(DAWN)研究结果
Diabet Med. 2005 Oct;22(10):1379-85. doi: 10.1111/j.1464-5491.2005.01644.x.
10
Quality of life, treatment satisfaction, and treatment preference associated with use of a pen device delivering a premixed 70/30 insulin aspart suspension (aspart protamine suspension/soluble aspart) versus alternative treatment strategies.与使用预混70/30门冬胰岛素混悬液(精蛋白门冬胰岛素混悬液/可溶性门冬胰岛素)笔式装置相比其他治疗策略相关的生活质量、治疗满意度及治疗偏好。
Diabetes Care. 2004 Oct;27(10):2495-7. doi: 10.2337/diacare.27.10.2495.

两种胰岛素笔的直观性、易用性及偏好性比较。

Comparison of intuitiveness, ease of use, and preference in two insulin pens.

作者信息

Asakura Toshinari, Jensen Klaus H

机构信息

Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan.

出版信息

J Diabetes Sci Technol. 2009 Mar 1;3(2):312-9. doi: 10.1177/193229680900300212.

DOI:10.1177/193229680900300212
PMID:20144362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2771516/
Abstract

BACKGROUND

The intuitiveness, instruction time, and handling of the Levemir (insulin detemir) FlexPen and the Lantus OptiClik pen (with insulin glargine) were investigated.

METHODS

This randomized open-label crossover study involved two groups of insulin-device-naive Japanese patients with type 2 diabetes [mean (SD) age 61.9 +/- 12.3 years, 57% male]. Patients were evaluated on the ease-of-use of each insulin pen without instruction [intuitiveness group (n = 32)], or with instruction [instruction time group (n = 29)]. Patient preferences for the respective devices were assessed by questionnaire.

RESULTS AND DISCUSSION

FlexPen required significantly less instruction time (p < .001) and was objectively more intuitive to use (p < .001) than OptiClik. Nevertheless, few patients in the intuitiveness group felt confident injecting either pen prior to instruction (FlexPen, 31%; OptiClik, 16%). No patients in the instruction time group found FlexPen difficult to learn, whereas 45% of patients found OptiClik difficult or very difficult to learn. FlexPen was rated simpler to use (77% versus 12%; p < .001), easier to inject (67% versus 13%; p < .001), and more convenient (71% versus 12%; p < .001) compared with OptiClik. More patients would trust FlexPen to deliver insulin injections (p < .01) and would prefer to use FlexPen compared with OptiClik (82% versus 13%; p < .001).

CONCLUSIONS

FlexPen was faster to teach, simpler to use, and more trusted by patients compared with OptiClik. Mean injection time was significantly shorter for FlexPen than OptiClik, with or without instruction. This study highlights not only how easy it is for patients to learn to use FlexPen, but also how easily health care providers can teach patients to use it.

摘要

背景

对来得时(胰岛素 detemir)预填充注射笔和甘李药业的畅充胰岛素笔(含胰岛素 glargine)的直观性、操作说明时间及使用情况进行了研究。

方法

这项随机开放标签交叉研究纳入了两组之前未使用过胰岛素笔的日本 2 型糖尿病患者[平均(标准差)年龄 61.9±12.3 岁,57%为男性]。在无操作说明的情况下评估患者对每种胰岛素笔的易用性[直观性组(n = 32)],或在有操作说明的情况下评估[操作说明时间组(n = 29)]。通过问卷调查评估患者对各设备的偏好。

结果与讨论

与畅充胰岛素笔相比,来得时预填充注射笔所需的操作说明时间显著更少(p <.001),且在客观上使用起来更直观(p <.001)。然而,在直观性组中,很少有患者在接受操作说明前对使用这两种笔进行注射有信心(来得时预填充注射笔为 31%;畅充胰岛素笔为 16%)。操作说明时间组中没有患者觉得来得时预填充注射笔难学,而 45%的患者觉得畅充胰岛素笔难学或非常难学。与畅充胰岛素笔相比,来得时预填充注射笔被评为使用更简单(77%对 12%;p <.001)、注射更容易(67%对 13%;p <.001)且更方便(71%对 12%;p <.001)。更多患者会信赖来得时预填充注射笔进行胰岛素注射(p <.01),且与畅充胰岛素笔相比,更多患者更愿意使用来得时预填充注射笔(82%对 13%;p <.001)。

结论

与畅充胰岛素笔相比,来得时预填充注射笔教学更快、使用更简单且更受患者信赖。无论有无操作说明,来得时预填充注射笔的平均注射时间均显著短于畅充胰岛素笔。这项研究不仅凸显了患者学习使用来得时预填充注射笔有多容易,也凸显了医护人员教导患者使用它有多容易。