Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
Students' Scientific Association by the Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
Front Endocrinol (Lausanne). 2022 Mar 8;13:827484. doi: 10.3389/fendo.2022.827484. eCollection 2022.
Currently, there are about 150-200 million diabetic patients treated with insulin globally. The year 2021 is special because the 100th anniversary of the insulin discovery is being celebrated. It is a good occasion to sum up the insulin pen technology invention and improvement which are nowadays the leading mode of an insulin delivery. Even though so many years have passed, insulin is still administered subcutaneously, that is why devices to deliver it are of great importance. Insulin pens have evolved only through the last decades (the reusable, durable pens, and the disposable, prefilled pens) and modern smart insulin pens have been developed in the last few years, and both types of the devices compared to traditional syringes and vials are more convenient, discrete in use, have better dosing accuracy, and improve adherence. In this review, we will focus on the history of insulin pens and their improvement over the previous decades.
目前，全球约有 1.5 亿至 2 亿糖尿病患者接受胰岛素治疗。2021 年是特殊的一年，因为正在庆祝胰岛素发现 100 周年。这是总结胰岛素笔技术发明和改进的好机会，目前它是胰岛素输送的主要模式。尽管已经过去了这么多年，胰岛素仍然是皮下给药，这就是为什么输送它的设备非常重要。胰岛素笔在过去几十年中才得到发展（可重复使用、耐用的笔和一次性、预填充的笔），并且在过去几年中已经开发出了现代智能胰岛素笔，与传统的注射器和小瓶相比，这两种类型的设备更方便、使用更隐蔽、剂量更精确，并提高了患者的顺应性。在这篇综述中，我们将重点介绍胰岛素笔的历史及其在过去几十年中的改进。
