Instituto Aggeu Magalhães, Fundação Oswaldo Cruz (Fiocruz), Recife, Pernambuco, Brazil.
Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis.
Parasit Vectors. 2023 Apr 28;16(1):148. doi: 10.1186/s13071-023-05690-8.
Dirofilaria immitis (the canine heartworm) is widespread in the tropics, with prevalence surpassing 30% in high-risk areas. In addition to the suitable climatic conditions that favour mosquito abundance and filarial larva development, there is low compliance with the recommended year-round use of preventives in these transmission hotspots. This represents a major concern, considering that melarsomine (first-line heartworm adulticide) is unavailable in several tropical countries, resulting in the so-called slow-kill protocol being the only available adulticide treatment option. In this article, the members of TroCCAP (Tropical Council for Companion Animal Parasites) review the current distribution of heartworm in the tropics and the availability of melarsomine, and discuss alternatives for the management of heartworm infections in dogs.
犬恶丝虫（犬心丝虫）广泛分布于热带地区，在高风险地区的流行率超过 30%。除了有利于蚊子滋生和丝虫幼虫发育的适宜气候条件外，在这些传播热点地区，人们对推荐的全年使用预防药物的依从性较低。这是一个主要的关注点，因为几种热带国家都没有供应美拉胂醇（一线犬心丝虫成虫杀虫剂），这导致所谓的慢杀方案成为唯一可用的成虫杀虫剂治疗选择。在本文中，热带伴侣动物寄生虫理事会（Tropical Council for Companion Animal Parasites，简称 TroCCAP）的成员回顾了热带地区目前的心丝虫分布情况和美拉胂醇的供应情况，并讨论了犬心丝虫感染管理的替代方案。
