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新型 FKS 突变与棘白菌素类耐药的念珠菌属相关。

Novel FKS mutations associated with echinocandin resistance in Candida species.

机构信息

Public Health Research Institute, Newark, New Jersey, USA.

出版信息

Antimicrob Agents Chemother. 2010 May;54(5):2225-7. doi: 10.1128/AAC.00998-09. Epub 2010 Feb 9.

DOI:10.1128/AAC.00998-09
PMID:20145084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2863628/
Abstract

We studied three clinical isolates of Candida spp. (one C. tropicalis isolate and two C. glabrata isolates) from patients with invasive candidiasis. The first isolate emerged during echinocandin treatment, while the others emerged after the same treatment. These strains harbored an amino acid substitution in Fksp never linked before with reduced echinocandin susceptibility in C. tropicalis or in C. glabrata. The molecular mechanism of reduced susceptibility was confirmed using a 1,3-beta-D-glucan synthase inhibition assay.

摘要

我们研究了三株来自侵袭性念珠菌病患者的念珠菌属（一株热带念珠菌和两株光滑念珠菌）的临床分离株。第一株分离株在棘白菌素治疗期间出现，而其他两株在相同治疗后出现。这些菌株携带了以前从未与棘白菌素敏感性降低相关的 Fksp 氨基酸取代，这种敏感性降低在热带念珠菌或光滑念珠菌中从未出现过。使用 1,3-β-D-葡聚糖合酶抑制试验证实了这种低敏感性的分子机制。

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