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光滑念珠菌感染继发侵袭性念珠菌病长期治疗后卡泊芬净耐药性的产生。

Development of caspofungin resistance following prolonged therapy for invasive candidiasis secondary to Candida glabrata infection.

作者信息

Thompson George R, Wiederhold Nathan P, Vallor Ana C, Villareal Nyria C, Lewis James S, Patterson Thomas F

机构信息

Department of Internal Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

出版信息

Antimicrob Agents Chemother. 2008 Oct;52(10):3783-5. doi: 10.1128/AAC.00473-08. Epub 2008 Aug 1.

DOI:10.1128/AAC.00473-08
PMID:18676885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2565919/
Abstract

We report a case of Candida glabrata invasive candidiasis that developed reduced susceptibility to caspofungin during prolonged therapy. Pre- and posttreatment isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed an F659V substitution within the FKS2 region of the glucan synthase complex.

摘要

我们报告了1例光滑念珠菌侵袭性念珠菌病病例，该病例在长期治疗期间对卡泊芬净的敏感性降低。治疗前和治疗后的分离株经确认是同基因的，对已知赋予棘白菌素耐药性的热点区域进行测序，结果显示葡聚糖合酶复合体的FKS2区域内有一个F659V替换。

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本文引用的文献

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Reduced Candida glabrata susceptibility secondary to an FKS1 mutation developed during candidemia treatment.念珠菌血症治疗期间因FKS1突变导致光滑念珠菌敏感性降低。
Antimicrob Agents Chemother. 2008 Jun;52(6):2263-5. doi: 10.1128/AAC.01568-07. Epub 2008 Mar 31.
2
Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis.米卡芬净与卡泊芬净治疗念珠菌血症及其他侵袭性念珠菌病的比较。
Clin Infect Dis. 2007 Oct 1;45(7):883-93. doi: 10.1086/520980. Epub 2007 Aug 29.
3
Anidulafungin versus fluconazole for invasive candidiasis.阿尼芬净与氟康唑治疗侵袭性念珠菌病的比较
N Engl J Med. 2007 Jun 14;356(24):2472-82. doi: 10.1056/NEJMoa066906.
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Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trial.米卡芬净与脂质体两性霉素B治疗念珠菌血症和侵袭性念珠菌病：一项III期随机双盲试验
Lancet. 2007 May 5;369(9572):1519-1527. doi: 10.1016/S0140-6736(07)60605-9.
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Serum differentially alters the antifungal properties of echinocandin drugs.血清可不同程度地改变棘白菌素类药物的抗真菌特性。
Antimicrob Agents Chemother. 2007 Jun;51(6):2253-6. doi: 10.1128/AAC.01536-06. Epub 2007 Apr 9.
6
Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase.一株克鲁斯假丝酵母因葡聚糖合酶修饰而获得棘白菌素耐药性。
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In vivo efficacy of anidulafungin and caspofungin against Candida glabrata and association with in vitro potency in the presence of sera.阿尼芬净和卡泊芬净对光滑念珠菌的体内疗效以及在血清存在下与体外效力的相关性。
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In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility.阿尼芬净和卡泊芬净对光滑念珠菌分离株的体外药效学研究，包括对卡泊芬净敏感性降低的菌株。
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Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility.白色念珠菌和光滑念珠菌临床分离株对棘白菌素的敏感性降低。
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Progressive esophagitis caused by Candida albicans with reduced susceptibility to caspofungin.由对卡泊芬净敏感性降低的白色念珠菌引起的进行性食管炎。
Pharmacotherapy. 2006 Jun;26(6):877-80. doi: 10.1592/phco.26.6.877.