来自嗜水气单胞菌的 PER-6，一种广谱β-内酰胺酶。
PER-6, an extended-spectrum beta-lactamase from Aeromonas allosaccharophila.
机构信息
Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, 94275 Le Kremlin-Bicêtre Cedex, France.
出版信息
Antimicrob Agents Chemother. 2010 Apr;54(4):1619-22. doi: 10.1128/AAC.01585-09. Epub 2010 Feb 9.
Abstract
An Aeromonas allosaccharophila environmental isolate recovered from the Seine River (Paris, France) produced a novel extended-spectrum beta-lactamase, PER-6, that shared 92% amino acid identity with the closest ss-lactamase, PER-2. The kinetic properties of PER-6 showed a slightly increased affinity for carbapenems. The bla(PER-6) gene was chromosomally located and bracketed by non-transposon-related structures.
摘要
从法国塞纳河（巴黎）采集的一株嗜水气单胞菌环境分离株产生了一种新型的超广谱β-内酰胺酶 PER-6，与最接近的 ss-内酰胺酶 PER-2 具有 92%的氨基酸同一性。PER-6 的动力学特性显示对碳青霉烯类药物的亲和力略有增加。bla(PER-6)基因位于染色体上，被非转座子相关结构包围。
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