来自法国巴黎塞纳河的荧光假单胞菌分离株的新型 Ambler 类 A 碳青霉烯水解β-内酰胺酶。
Novel ambler class A carbapenem-hydrolyzing beta-lactamase from a Pseudomonas fluorescens isolate from the Seine River, Paris, France.
机构信息
Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cédex, France.
出版信息
Antimicrob Agents Chemother. 2010 Jan;54(1):328-32. doi: 10.1128/AAC.00961-09. Epub 2009 Nov 9.
Abstract
A Pseudomonas fluorescens isolate (PF-1) resistant to carbapenems was recovered during an environmental survey performed with water from the Seine River (Paris). It expressed a novel Ambler class A carbapenemase, BIC-1, sharing 68 and 59% amino acid identities with beta-lactamases SFC-1 from Serratia fonticola and the plasmid-encoded KPC-2, respectively. beta-Lactamase BIC-1 hydrolyzed penicillins, carbapenems, and cephalosporins except ceftazidime and monobactams. The bla(BIC-1) gene was chromosomally located and was also identified in two other P. fluorescens strains isolated from the Seine River 3 months later.
摘要
一株抗碳青霉烯类抗生素的荧光假单胞菌（PF-1）是从塞纳河（巴黎）的水样环境调查中分离得到的。它表达了一种新型的 Ambler 类 A 碳青霉烯酶，BIC-1，与来自粘质沙雷氏菌的 SFC-1 及质粒编码的 KPC-2 分别具有 68%和 59%的氨基酸同一性。β-内酰胺酶 BIC-1 可水解青霉素类、碳青霉烯类和头孢菌素类抗生素，但不能水解头孢他啶和单环β-内酰胺类抗生素。bla（BIC-1）基因位于染色体上，3 个月后从塞纳河分离的另外两株荧光假单胞菌中也发现了该基因。
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