Jenkins Stephen J, Allen Judith E
Institute of Immunology & Infection Research, University of Edinburgh, Edinburgh EH9 3JT, UK.
J Biomed Biotechnol. 2010;2010:262609. doi: 10.1155/2010/262609. Epub 2010 Jan 26.
This review summarizes current knowledge of macrophages in helminth infections, with a focus not only on delineating the striking similarities in macrophage phenotype between diverse infections but also on highlighting the differences. Findings from many different labs illustrate that macrophages in helminth infection can act as anti-parasite effectors but can also act as powerful immune suppressors. The specific role for their alternative (Th2-mediated) activation in helminth killing or expulsion versus immune regulation remains to be determined. Meanwhile, the rapid growth in knowledge of alternatively activated macrophages will require an even more expansive view of their potential functions to include repair of host tissue and regulation of host metabolism.
本综述总结了目前关于巨噬细胞在蠕虫感染中的知识，不仅着重阐述不同感染中巨噬细胞表型的显著相似性，还突出其差异。许多不同实验室的研究结果表明，蠕虫感染中的巨噬细胞既可以作为抗寄生虫效应细胞，也可以作为强大的免疫抑制细胞。其在蠕虫杀伤或排出以及免疫调节中通过替代性（Th2介导）激活所发挥的具体作用仍有待确定。与此同时，随着对替代性激活巨噬细胞的认识迅速增加，需要更全面地看待其潜在功能，包括宿主组织修复和宿主代谢调节。
