Santa Casa de Misericórdia de São Paulo, Sao Paulo, Brazil.
J Neurooncol. 2010 Oct;100(1):9-15. doi: 10.1007/s11060-010-0137-5. Epub 2010 Feb 10.
Bone involvement is a common finding in many types of lymphoma (Clin Oncol 9(3): 195-196, 1997). However, cranial vault affliction has been regarded as an exceedingly rare presentation, particularly in the case of primary lymphoma (J Neurosurg 108(5): 1018-1020, 2008). Our objective is to describe a series of five immunocompetent patients with histologically confirmed cranial vault lymphoma (CVL), and to conduct a systematic review of the current literature. Our review points out identical imaging patterns in most of the lesions for all reported CVL cases, despite their different histological subtypes. This typical pattern can be seen on computed tomography (CT) scans and magnetic resonance imaging (MRI) as an expansive tumor that affects all three compartments of the cranial vault, including the scalp, skull bone, and pachymeninges, even in the absence of osteolysis. We argue that the absence of osteolysis might enhance diagnostic capability. In the appropriate clinical setting, these features represent important disease characteristics that may help with an earlier diagnosis. Large B-cell lymphoma was the most common subtype of primary CVL.
骨骼侵犯是许多类型淋巴瘤的常见表现（Clin Oncol 9(3): 195-196, 1997）。然而，颅骨受累被认为是一种极其罕见的表现，尤其是原发性淋巴瘤（J Neurosurg 108(5): 1018-1020, 2008）。我们的目的是描述 5 例经组织学证实的颅骨原发性淋巴瘤（CVL）的免疫功能正常的患者，并对当前的文献进行系统回顾。我们的综述指出，尽管报道的 CVL 病例具有不同的组织学亚型，但大多数病变的影像学模式相同。在计算机断层扫描（CT）和磁共振成像（MRI）上，这种典型的模式表现为一种扩张性肿瘤，影响颅骨穹窿的所有三个部分，包括头皮、颅骨和硬脑膜，即使没有溶骨性破坏。我们认为，没有溶骨性破坏可能会增强诊断能力。在适当的临床环境下，这些特征是重要的疾病特征，可能有助于更早地诊断。大 B 细胞淋巴瘤是原发性 CVL 最常见的亚型。
