Psychology Department, University of New Orleans, 2005 Geology & Psychology Building, New Orleans, LA 70148, USA.
J Abnorm Child Psychol. 2010 Jul;38(5):633-43. doi: 10.1007/s10802-010-9392-3.
Personality traits may be viable candidates for mediators of the relationship between genetic risk and ADHD. Participants were 578 children (331 boys; 320 children with ADHD) between the ages of six and 18. Parents and teachers completed a comprehensive, multi-stage diagnostic procedure to assess ADHD and comorbid disorders. Mother completed the California Q-Sort to assess child Big Five personality traits. Children provided buccal samples of DNA which were assayed for selected markers on DRD4, DAT1, and ADRA2A. An additive genetic risk composite was associated with ADHD symptoms and maladaptive personality traits; maladaptive personality traits were associated with ADHD symptoms. Low conscientiousness and high neuroticism partially mediated the relationship between genetic risk and ADHD symptoms. Mediation effects for conscientiousness were specific to inattentive symptoms; effects for neuroticism generalized to all disruptive behaviors. High neuroticism and low conscientiousness may be useful as early markers for children at risk for ADHD.
人格特质可能是遗传风险与 ADHD 之间关系的中介变量的候选者。参与者为 578 名儿童（331 名男孩；320 名 ADHD 儿童），年龄在 6 至 18 岁之间。父母和教师完成了全面的、多阶段的诊断程序，以评估 ADHD 和共病障碍。母亲完成了加利福尼亚 Q 分类法，以评估儿童的大五人格特质。儿童提供了口腔样本的 DNA，这些 DNA 被用于检测 DRD4、DAT1 和 ADRA2A 上的选定标记。累积遗传风险与 ADHD 症状和适应不良的人格特质相关；适应不良的人格特质与 ADHD 症状相关。低尽责性和高神经质部分中介了遗传风险与 ADHD 症状之间的关系。尽责性的中介作用特定于注意力不集中的症状；神经质的作用普遍适用于所有破坏性行为。高神经质和低尽责性可能是 ADHD 高危儿童的有用早期标志物。
