人格对注意缺陷多动障碍遗传效应的中介作用。
Personality mediation of genetic effects on Attention-Deficit/Hyperactivity Disorder.
机构信息
Psychology Department, University of New Orleans, 2005 Geology & Psychology Building, New Orleans, LA 70148, USA.
出版信息
J Abnorm Child Psychol. 2010 Jul;38(5):633-43. doi: 10.1007/s10802-010-9392-3.
Abstract
Personality traits may be viable candidates for mediators of the relationship between genetic risk and ADHD. Participants were 578 children (331 boys; 320 children with ADHD) between the ages of six and 18. Parents and teachers completed a comprehensive, multi-stage diagnostic procedure to assess ADHD and comorbid disorders. Mother completed the California Q-Sort to assess child Big Five personality traits. Children provided buccal samples of DNA which were assayed for selected markers on DRD4, DAT1, and ADRA2A. An additive genetic risk composite was associated with ADHD symptoms and maladaptive personality traits; maladaptive personality traits were associated with ADHD symptoms. Low conscientiousness and high neuroticism partially mediated the relationship between genetic risk and ADHD symptoms. Mediation effects for conscientiousness were specific to inattentive symptoms; effects for neuroticism generalized to all disruptive behaviors. High neuroticism and low conscientiousness may be useful as early markers for children at risk for ADHD.
摘要
人格特质可能是遗传风险与 ADHD 之间关系的中介变量的候选者。参与者为 578 名儿童（331 名男孩；320 名 ADHD 儿童），年龄在 6 至 18 岁之间。父母和教师完成了全面的、多阶段的诊断程序，以评估 ADHD 和共病障碍。母亲完成了加利福尼亚 Q 分类法，以评估儿童的大五人格特质。儿童提供了口腔样本的 DNA，这些 DNA 被用于检测 DRD4、DAT1 和 ADRA2A 上的选定标记。累积遗传风险与 ADHD 症状和适应不良的人格特质相关；适应不良的人格特质与 ADHD 症状相关。低尽责性和高神经质部分中介了遗传风险与 ADHD 症状之间的关系。尽责性的中介作用特定于注意力不集中的症状；神经质的作用普遍适用于所有破坏性行为。高神经质和低尽责性可能是 ADHD 高危儿童的有用早期标志物。
相似文献
1
Personality mediation of genetic effects on Attention-Deficit/Hyperactivity Disorder.人格对注意缺陷多动障碍遗传效应的中介作用。
J Abnorm Child Psychol. 2010 Jul;38(5):633-43. doi: 10.1007/s10802-010-9392-3.
2
Diversity in pathways to common childhood disruptive behavior disorders.常见儿童行为障碍发病途径的多样性。
J Abnorm Child Psychol. 2012 Nov;40(8):1223-36. doi: 10.1007/s10802-012-9646-3.
3
Relations between multi-informant assessments of ADHD symptoms, DAT1, and DRD4.多动症症状、多巴胺转运体1（DAT1）和多巴胺D4受体（DRD4）的多信息提供者评估之间的关系
J Abnorm Psychol. 2008 Nov;117(4):869-80. doi: 10.1037/a0013297.
4
Double dissociation between lab measures of inattention and impulsivity and the dopamine transporter gene (DAT1) and dopamine D4 receptor gene (DRD4).注意缺陷多动障碍的实验室测量与多巴胺转运体基因（DAT1）和多巴胺 D4 受体基因（DRD4）之间的双重分离。
J Abnorm Psychol. 2012 Nov;121(4):1011-23. doi: 10.1037/a0028225. Epub 2012 May 7.
5
A family based association study of DRD4, DAT1, and 5HTT and continuous traits of attention-deficit hyperactivity disorder.DRD4、DAT1 和 5-HTT 与注意缺陷多动障碍连续特征的基于家庭的关联研究。
Behav Genet. 2011 Jan;41(1):165-74. doi: 10.1007/s10519-010-9437-y. Epub 2011 Jan 5.
6
Dopamine risk and paternal ADHD symptomatology associated with ADHD symptoms in four and a half-year-old boys.多巴胺风险及父亲的多动症症状与四岁半男孩的多动症症状相关。
Psychiatr Genet. 2010 Aug;20(4):160-5. doi: 10.1097/YPG.0b013e32833a1f27.
7
Genetics of preparation and response control in ADHD: the role of DRD4 and DAT1.注意缺陷多动障碍中准备与反应控制的遗传学：多巴胺D4受体基因（DRD4）和多巴胺转运体1基因（DAT1）的作用
J Child Psychol Psychiatry. 2014 Aug;55(8):914-23. doi: 10.1111/jcpp.12212. Epub 2014 Feb 13.
8
Genetic associations between ADHD and dopaminergic genes (DAT1 and DRD4) VNTRs in Korean children.韩国儿童注意力缺陷多动障碍（ADHD）与多巴胺能基因（DAT1和DRD4）可变数目串联重复序列（VNTRs）之间的遗传关联。
Genes Genomics. 2018 Dec;40(12):1309-1317. doi: 10.1007/s13258-018-0726-9. Epub 2018 Aug 11.
9
Effects of maternal and paternal smoking on attentional control in children with and without ADHD.父母吸烟对 ADHD 儿童和非 ADHD 儿童注意力控制的影响。
Eur Child Adolesc Psychiatry. 2009 Aug;18(8):465-75. doi: 10.1007/s00787-009-0001-3. Epub 2009 Mar 14.
10
Dopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: the case of conduct and emotional problems in attention deficit/hyperactivity disorder.多巴胺和5-羟色胺转运体基因类型调节对母亲表达性情绪的敏感性：注意力缺陷/多动障碍中行为和情绪问题的案例
J Child Psychol Psychiatry. 2009 Sep;50(9):1052-63. doi: 10.1111/j.1469-7610.2009.02095.x. Epub 2009 Apr 14.
引用本文的文献
1
Incremental Validity of ADHD Dimensions in the Predictions of Emotional Symptoms, Conduct Problems, and Peer Problems in Adolescents Based on Parent, Teacher, and Self-Ratings.基于家长、教师和自我评定，注意缺陷多动障碍维度对青少年情绪症状、行为问题和同伴问题预测的增量效度
Pediatr Rep. 2024 Dec 10;16(4):1115-1133. doi: 10.3390/pediatric16040095.
2
Negative Parenting Mediates the Longitudinal Association between Parental Internalizing Symptoms and Child Oppositional Symptoms.消极养育方式介导了父母内化症状与儿童对立症状之间的纵向关联。
Child Psychiatry Hum Dev. 2025 Apr;56(2):1-13. doi: 10.1007/s10578-023-01575-0. Epub 2023 Jul 21.
3
Mental health in Canadian children and adolescents during COVID-19 pandemic: the role of personality and, coping and stress responses.新冠疫情期间加拿大儿童和青少年的心理健康：人格、应对方式及应激反应的作用
Front Psychol. 2023 Jun 19;14:1190375. doi: 10.3389/fpsyg.2023.1190375. eCollection 2023.
4
Longitudinal Temperament Pathways to ADHD Between Childhood and Adolescence.ADHD 从儿童期到青少年期的纵向气质发展轨迹。
Res Child Adolesc Psychopathol. 2022 Aug;50(8):1055-1066. doi: 10.1007/s10802-022-00902-8. Epub 2022 Feb 1.
5
Personality profiles in adults with attention deficit hyperactivity disorder (ADHD).患有注意力缺陷多动障碍（ADHD）的成年人的人格特征。
BMC Psychiatry. 2016 Jun 14;16:199. doi: 10.1186/s12888-016-0906-6.
6
Testing for the mediating role of endophenotypes using molecular genetic data in a twin study of ADHD traits.在一项注意缺陷多动障碍（ADHD）特质的双生子研究中，利用分子遗传学数据检验内表型的中介作用。
Am J Med Genet B Neuropsychiatr Genet. 2016 Oct;171(7):982-92. doi: 10.1002/ajmg.b.32463. Epub 2016 May 27.
7
Personality Traits Elucidate Sex Differences in Attention-Deficit/Hyperactivity Disorder Comorbidity During Early Childhood.人格特质揭示幼儿期注意力缺陷/多动障碍共病中的性别差异。
J Psychopathol Behav Assess. 2014 Jun 1;36(2):237-245. doi: 10.1007/s10862-013-9382-1.
8
Adult attention deficit hyperactivity disorder symptoms and five-factor model traits in a clinical sample: a structural equation modeling approach.临床样本中的成人注意力缺陷多动障碍症状与五因素模型特质：一种结构方程建模方法
J Nerv Ment Dis. 2013 Oct;201(10):848-54. doi: 10.1097/NMD.0b013e3182a5bf33.
9
An examination of the specificity of motivation and executive functioning in ADHD symptom-clusters in adolescence.探讨青少年注意缺陷多动障碍症状群中动机和执行功能的特异性。
J Pediatr Psychol. 2013 Nov;38(10):1081-90. doi: 10.1093/jpepsy/jst050. Epub 2013 Jul 8.
10
Personality dimensions as common and broadband-specific features for internalizing and externalizing disorders.人格维度作为内倾和外倾障碍的共同和广谱特征。
J Abnorm Child Psychol. 2013 Aug;41(6):939-57. doi: 10.1007/s10802-013-9730-3.
本文引用的文献
1
Neural reward processing is modulated by approach- and avoidance-related personality traits.神经奖励处理受到趋近和回避相关人格特质的调节。
Neuroimage. 2010 Jan 15;49(2):1868-74. doi: 10.1016/j.neuroimage.2009.09.016. Epub 2009 Sep 18.
2
Individual differences in personality traits reflect structural variance in specific brain regions.人格特质的个体差异反映了特定脑区的结构差异。
Brain Res Bull. 2009 Jun 30;79(5):265-70. doi: 10.1016/j.brainresbull.2009.03.005. Epub 2009 Mar 28.
3
Shared and disorder-specific prefrontal abnormalities in boys with pure attention-deficit/hyperactivity disorder compared to boys with pure CD during interference inhibition and attention allocation.与单纯患有对立违抗性障碍（CD）的男孩相比，单纯患有注意力缺陷多动障碍（ADHD）的男孩在干扰抑制和注意力分配过程中前额叶存在共享的以及特定于该障碍的异常。
J Child Psychol Psychiatry. 2009 Jun;50(6):669-78. doi: 10.1111/j.1469-7610.2008.02022.x. Epub 2009 Jan 5.
4
Impact of the dopamine receptor gene family on temperament traits in a population-based birth cohort.多巴胺受体基因家族对一个基于人群的出生队列中气质特征的影响。
Am J Med Genet B Neuropsychiatr Genet. 2009 Sep 5;150B(6):854-65. doi: 10.1002/ajmg.b.30908.
5
Relations between multi-informant assessments of ADHD symptoms, DAT1, and DRD4.多动症症状、多巴胺转运体1（DAT1）和多巴胺D4受体（DRD4）的多信息提供者评估之间的关系
J Abnorm Psychol. 2008 Nov;117(4):869-80. doi: 10.1037/a0013297.
6
Corpus callosum morphology in children and adolescents with attention deficit hyperactivity disorder: a meta-analytic review.注意缺陷多动障碍儿童及青少年的胼胝体形态：一项荟萃分析综述
Neuropsychology. 2008 May;22(3):341-9. doi: 10.1037/0894-4105.22.3.341.
7
Parenting quality interacts with genetic variation in dopamine receptor D4 to influence temperament in early childhood.养育质量与多巴胺受体D4的基因变异相互作用，影响幼儿期的气质。
Dev Psychopathol. 2007 Fall;19(4):1039-46. doi: 10.1017/S0954579407000521.
8
Genotype and neuropsychological response inhibition as resilience promoters for attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder under conditions of psychosocial adversity.在社会心理逆境条件下，基因型和神经心理反应抑制作为注意缺陷多动障碍、对立违抗障碍和品行障碍的复原力促进因素。
Dev Psychopathol. 2007 Summer;19(3):767-86. doi: 10.1017/S0954579407000387.
9
Personality characteristics associated with persistent ADHD in late adolescence.与青少年晚期持续性注意力缺陷多动障碍相关的人格特征。
J Abnorm Child Psychol. 2008 Feb;36(2):165-73. doi: 10.1007/s10802-007-9167-7. Epub 2007 Aug 15.
10
Genetic support for the dual nature of attention deficit hyperactivity disorder: substantial genetic overlap between the inattentive and hyperactive-impulsive components.注意缺陷多动障碍双重性质的遗传学支持：注意力不集中和多动冲动成分之间存在大量基因重叠。
J Abnorm Child Psychol. 2007 Dec;35(6):999-1008. doi: 10.1007/s10802-007-9149-9. Epub 2007 Aug 10.
Zotero 插件