Pharmacy Department, Harper University Hospital/Hutzel Women's Hospital, Detroit Medical Center, Wayne State University, Detroit, Michigan 48201, USA.
Clin Infect Dis. 2010 Mar 15;50(6):e38-40. doi: 10.1086/650582.
The emergence of highly resistant gram-negative pathogens in hospitals around the world has placed emphasis on colistin, a seemingly ancient drug. Respiratory failure from colistin was reported in the years following its release; however, there are no recent reports of colistin-induced respiratory failure. We report a case of intravenous colistin- and, later, inhalational colistin-induced respiratory failure.
在世界各地的医院中,高度耐药的革兰氏阴性病原体的出现使人们对黏菌素这种看似古老的药物产生了重视。黏菌素上市后有报道称其可引起呼吸衰竭;然而,近期尚无黏菌素引起呼吸衰竭的报告。我们报告了一例静脉注射黏菌素和随后吸入黏菌素引起的呼吸衰竭。