Clarren Sterling K, Chudley Albert E, Wong Louis, Friesen Janis, Brant Rollin
Canada Northwest FASD Research Network, Vancouver, Canada.
Can J Clin Pharmacol. 2010 Winter;17(1):e67-78. Epub 2010 Feb 10.
Fetal alcohol syndrome (FAS) includes the facial dysmorphic feature of short palpebral fissures (PFs) and short PFs are a key physical marker for identifying children with FAS and some other rarer conditions. There is concern that normative data on PFs now available may not reflect all racial/ethnic groups and might be inaccurate in general.
To accomplish a large population based study that would accurately determine normative PF values across the full diversity of the Canadian school age population.
A normative sample of school age children was identified in Vancouver, British Columbia and Winnipeg, Manitoba to reflect the diversity of racial and national groups in Canada. The sample included students in grades 2, 4, 6, 8, and 10 from 17 schools in Vancouver and 31 schools in Winnipeg. Schools were selected based on racial diversity obtained from data from the 2001 Statistics Canada census. 1064 students in Vancouver and 1033 students in Winnipeg were photographed in a standardized way. Photographs were analyzed using a computerized method.
Analysis demonstrated that PFs do grow with age and there is a slight but meaningful difference between boys and girls in each age group. It is possible to define Canadian standards without reference to racial or ethnic origin.
Mean results with norms and standard deviations are presented in figures for clinical use and are clinically smaller than those found in the most commonly used reference book.
胎儿酒精综合征(FAS)包括睑裂短小这一面部畸形特征,睑裂短小是识别患有FAS及其他一些罕见病症儿童的关键身体标志。有人担心,目前可用的睑裂规范数据可能无法反映所有种族/族裔群体的情况,总体上可能不准确。
开展一项基于大量人群的研究,准确确定加拿大学龄人口全范围内的睑裂规范值。
在不列颠哥伦比亚省温哥华市和马尼托巴省温尼伯市确定了一个学龄儿童规范样本,以反映加拿大种族和民族群体的多样性。样本包括来自温哥华17所学校和温尼伯31所学校的二、四、六、八和十年级学生。学校是根据从2001年加拿大统计局人口普查数据中获得的种族多样性来选择的。对温哥华的1064名学生和温尼伯的1033名学生进行了标准化拍照。使用计算机化方法对照片进行分析。
分析表明,睑裂确实随着年龄增长,且每个年龄组的男孩和女孩之间存在轻微但有意义的差异。有可能在不考虑种族或族裔背景的情况下确定加拿大标准。
给出了带有规范值和标准差的平均结果数据供临床使用,这些数据在临床上比最常用参考书中的数据要小。